CALL RESULTS


Results of the 2015 JPco-fuND Transnational call

In 2015, JPND launched a joint transnational co-funded call in partnership with the European Commission under the ERA-NET Co-fund scheme in three JPND priority areas:

  • Longitudinal Cohort Approaches
  • Advanced Experimental Models
  • Risk and Protective Factors

Twenty-one projects were recommended for funding by the Peer Review Panel based on scientific excellence and by the Call Steering Committee based on budget availability.

To learn more about these projects, click on the project titles below. Proposals are presented in alphabetical order according to their acronym. Please refer to your national funding agency for further details. A list of the national contact representatives can be found here.

The supported projects are:

3DMiniBrain: High-Throughput, High-Content Screening of human neuroectodermal organoids for innovative drug discovery in neurodegenerative diseases
Topic: Advanced Experimental Models, Risk and Protective Factors
Coordinator:
JP Deslys, CEA, France
Partners:
Peter Heutink, DZNE, Germany
Giuseppe Legname, SISSA, Italy
JC Lambert, INSERM, France

3DPD: Advanced modelling of Parkinson’s disease with three-dimensional human midbrain organoids
Topic: Advanced Experimental Models
Coordinator:
Jens Schwamborn, University of Luxembourg
Partners:
Hans Schöler, Max Planck Institute for Molecular Biomedicine, Germany
Peter Ertl, Austrian Institute of Technology, Austria
Vincenzo Bonifati, Erasmus MC Rotterdam, Netherlands
Dror Seliktar, Technion – Israel Institute of Technology, Israel

ADAGE: Alzheimer’s Disease pathology within the ageing physiology
Topic: Risk and Protective Factors
Coordinator:
Claudio Franceschi, Azienda USL di Bologna, Italy
Partners:
Nancy Pedersen, Karolinska Institute, Sweden
Kevin Mills, University College of London, United Kingdom
Giorgio Giaccone, Istituto Besta Milano, Italy

aSynProtec: Alpha-synuclein pathology propagation in Parkinson’s disease and quest for novel protective strategies
Topic: Risk and Protective Factors
Coordinator:
Jia-Yi Li, Lund University, Sweden
Partners:
Tiago Outeiro, University Medical Center Goettingen, Germany
Olaf Riess, University of Tuebingen, Germany
Pekka Kallunki, H. Lundbeck A/S Copenhagen, Denmark
Daniel Otzen, Aarhus University, Denmark
Richard Wade-Martins, University of Oxford, United Kingdom
Jeroen Raes, Leuven University, Belgium
Hilal Lashuel, Swiss Federal Institute of Technology Lausanne, Switzerland

BRIDGET: BRain Imaging, cognition, Dementia and next generation GEnomics: a Transdisciplinary approach to search for risk and protective factors of neurodegenerative disease
Topic: Risk and Protective Factors
Coordinator:
Stéphanie Debette, Inserm U897, University of Bordeaux, France
Partner:
Helena Schmidt, Medical University Graz, Austria
Tomi Pastinen and Mark Lathrop, McGill Genome Center, Montréal, Canada
Hans J Grabe, Medical University of Greifswald, Germany
M Arfan Ikram, Erasmus MC University Medical Center, Rotterdam, the Netherlands
Ian Deary, University of Edinburgh, Scotland
Günter Schumann, King’s College, London, UK
Perminder Sachdev, University of New South Wales, Randwick NSW, Australia

CircProt: Synaptic circuit protection in Alzheimers’s disease (AD) and Huntingtion’s disease (HD): BDNF/TrkB and Arc signaling as rescue factors
Topic: Advanced Experimental Models, Risk and Protective Factors
Coordinator:
Volkmar Lessmann: Institute of Physiology, Otto-von-Guericke-University Magdeburg, Germany
Partners:
Eero Castren: Neuroscience Center, University of Helsinki, Finland
Hélène Marie: IPMC-CNRS UMR7275, Valbonne, France
Clive Bramham: Department of Biomedicine, University of Bergen, Norway
Frédéric Saudou: GIN, INSERM U1216, University Grenoble Alpes, France
Kurt Gottmann: Institute of Neuro- and Sensory Physiology, Heinrich-Heine-University Düsseldorf, Germany
Michele Migliore: National Research Council, Institute of Biophysics, Palermo, Italy
Elena Cattaneo: Department of Biosciences, University of Milano, Italy

CureALS: Stress granules and proteostasis in motor neurons: towards a mechanistic understanding of ALS
Topic: Advanced Experimental Models, Risk and Protective Factors
Coordinator:
Simon Alberti, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Partners:
Daniel Kaganovich, Hebrew University, Israel
Serena Carra, Università degli Studi di Modena e Reggio Emilia, Italy
Jared Sterneckert, Center for Regenerative Therapies Dresden, Germany
Angelo Poletti, Università degli studi di Milano, Italy
Nico Dantuma, Karolinska Institutet, Sweden
Adriano Aguzzi, University of Zurich, Switzerland

DACAPO-AD: Deciphering Interactions of Acquired Risk Factors and ApoE-mediated Pathways in Alzheimer’s Disease
Topic: Advanced Experimental Models
Coordinator:
Gabor Petzold, German Center for Neurodegenerative Diseases, Bonn, Germany
Partners:
Maiken Nedergaard, University of Copenhagen, Denmark
Michael Heneka, University of Bonn, Germany
Christian Göritz, Karolinska Institutet, Sweden
Stephane Oliet, INSERM U862, France

EADB: A European DNA bank for deciphering the missing heritability of Alzheimer’s disease
Topic: Risk and Protective Factors
Coordinator:
Jean-Charles Lambert, Université de Lille, Inserm UMR1167, Institut Pasteur de Lille, Lille, France
Partners:
Alfredo Ramirez, Rheinische-Friedrich-Wilhelms-Universität Bonn, Germany
Mikko Hiltunen, University of Eastern Finland
Giacomina Rossi, Foundation Carlo Besta Neurological Institute, Italy
Wiesje Van der Flier, VU University Medical Center, Amsterdam, Netherlands
Martin Ingelsson, Uppsala University, Sweden
Rebecca Sims, Cardiff University, UK
Frank Jessen, University Hospital Cologne, Germany
Karen Mather, University of New South Wales, Australia

EPI-AD: Targeting epigenetic dysregulation in the brainstem in Alzheimer’s disease
Topic: Advanced Experimental Models, Risk and Protective Factors
Coordinator:
Daniel van den Hove, Maastricht University, Netherlands
Partners:
Katie Lunnon, University of Exeter, UK
Thomas Haaf, University of Würzburg, Germany
Alfredo Ramirez, University of Bonn, Germany
Michael Wagner, German Center for Neurodegenerative Diseases, Bonn, Germany
Antonio Del Sol, Luxembourg Centre for Systems Biomedicine, Luxembourg
Manel Esteller, Bellvitge Biomedical Research Institute, Spain

ESMI: European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
Topic: Longitudinal Cohort Approaches
Coordinator:
Thomas Klockgether, German Center for Neurodegenerative Diseases, Bonn, Germany
Partners:
Paola Giunti, University College London, United Kingdom
Manuela Lima, University of Azores, Portugal
Luís Pereira de Almeida, University of Coimbra, Portugal
Olaf Riess, University of Tübingen, Germany
Ludger Schöls, University of Tübingen, Germany
Bart van de Warrenburg, Radboud University, Nijmegen, Netherlands

GBA-PARK: GBA1 mutations in Parkinson disease: clinical and biochemical prodrome, risk profile and pathogenetic modelling for therapeutic intervention
Topic: Advanced Experimental Models, Longitudinal Cohort Approaches, Risk and Protective Factors
Coordinator:
Anthony Schapira, UCL Institute of Neurology
Partners:
Fabio Blandini, IRCCS C. Mondino National Neurological Institut, Pavia, Italy
Donato Di Monte, DZNE, Bonn, Germany
Paolo Ciana, University of Milan, Italy
David Park, University of Ottawa, Canada

INSTALZ: Genomic Instability in Alzheimer’s Disease and Related Disorders: a Single-Cell Approach
Topic: Risk and Protective Factors
Coordinator:
Bart Dermaut, Université de Lille, Inserm U1167, CHU Lille, Institut Pasteur de Lille, Lille, France
Partners:
Marie-Christine Galas, Centre de Recherche Jean-Pierre Aubert, Inserm UMR-S1172, Lille, France
Thierry Voet, Sanger Institute-EBI Single-Cell Genomics Centre, Cambridge, UK
Bart De Strooper, KU Leuven, Belgium
Vilhelm Bohr, Copenhagen University, Denmark
Joakim Lundeberg, KTH Royal Institute of Technology, Stockholm, Sweden

MADGIC: Generation of Improved Cellular and Animal Models for Identification of Disease Phenotype and New Therapeutic Targets of Alzheimer’s Disease
Topic: Advanced Experimental Models
Coordinator:
Jari Koistinaho, University of Eastern Finland, Finland
Partners:
Laurent Roybon, University of Lund, Sweden
Gunnar Gouras, University of Lund, Sweden
Claire Rampon, University of Toulouse, France
Dora Brites, University of Lisbon, Portugal
Michael T. Heneka, University Hospital of Bonn, Germany
Frank Edenhofer, University of Wurzburg, Germany
Tarja Malm, University of Eastern Finland, Finland

ModelPolyQ: Advanced models of polyglutamine disorders (HD, SCA3 and SCA7)
Topic: Advanced Experimental Models
Coordinator:
Luis Pereira de Almeida, Center for Neuroscience and Cell Biology of Coimbra
Partners:
Huu Phuc Nguyen, EKUT, University of Tuebingen, Institute of Medical Genetics and Applied Genomics
Yvon Trottier, IGBMC/CNRS/INSERM/UNISTRA
Nicole Déglon, Lausanne University Hospital (CHUV)
Anselme Perrier, Inserm/UEVE U861
Elena Cattaneo, University of Milan

NAB3: Development of a Novel Multicellular In Vitro Model of Alzheimer’s disease-like Blood-Brain Barrier
Topic: Advanced Experimental Models
Coordiantor:
Francesca Re, University of Milano-Bicocca, Italy
Partners:
Claudia Almeida, Universidade NOVA de Lisboa, Portugal
Thomas G. Ohm, Charite Universitätsmedizin Berlin, Germany
Wiep Scheper, VU University Medical Center, Netherlands
Sandrine Bourdoulous, Inserm, Institut Cochin, Paris, France

PROP-AD: Propagation behaviour of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier
Topic: Advanced Experimental Models
Project website
Coordinator:
Jens Pahnke, University of Oslo, Norway
Partners:
Claus Pietrzik, Johannes Gutenberg University, Mainz, Germany
Dan Frenkel, Tel Aviv University, Israel
Maciej Lalowski, University of Helsinki, Finland
Henrik Biverstål, Karolinska Institutet, Huddinge, Sweden

REfrAME: Pathway complexities of protein misfolding in neurodegenerative diseases: a novel approach to risk evaluation and model development
Topic: Advanced Experimental Models, Risk and Protective Factors
Coordinator:
Giuseppe Legname, SISSA, Trieste, Italy
Partners:
Giuseppe Di Fede, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy
Mathias Jucker, German Center for Neurodegenerative Diseases, Tübingen, Germany
Michel Goedert, MRC Laboratory of Molecular Biology, Cambridge, UK
Jia-Yi Li, Lund University, Sweden
Adriano Aguzzi, University of Zurich, Switzerland
Michal Novak, Slovak Academy of Sciences, Bratislava, Slovakia

SNOWBALL: The interplay of amyloid and ischemia and their influence on the blood-brain barrier, amyloid transportation systems and neurodegeneration in cerebral amyloid angiopathy (CAA)
Topic: Advanced Experimental Models, Risk and Protective Factors
Coordiantor:
Marc Fatar, Universitätsmedizin Mannheim, University of Heidelberg, Germany
Partners:
Laurence Fenart, Universite D´Artois, Lens, France
Rick M. Dijkhuizen, Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands
K. Fassbender, Saarland University, Homburg, Germany
Mar Hernández-Guillamon, Vall d’Hebron Research Institute, Barcelona, Spain

STAD: Synapse-to-nucleus communication in Alzheimer’s disease
Topic: Advanced Experimental Models
Coordinator:
Monica Di Luca, University of Milano, Italy
Partners:
Christophe Mulle, UMR CNRS 5297, Université de Bordeaux, France
Michael R. Kreutz, Leibniz Institute for Neurobiology, Magdeburg, Germany

SYNACTION: Unravelling the pathophysiological role of alpha-synuclein aggregation, transmission and neuroinflammation in neurodegeneration
Topic: Advanced Experimental Models, Risk and Protective Factors
Coordinator:
Veerle Baekelandt, KU Leuven, Belgium
Partners:
Ronald Melki, Paris-Saclay Institute of Neuroscience, Gif-sur-Yvette, France
Michael Heneka, University of Bonn, Germany
Stéphane Hunot, Brain & Spine Institute, Paris, France