Call Results

Results of the 2013 JPND Transnational call for “European research projects for Cross-Disease Analysis of Pathways related to Neurodegenerative Diseases”

The following project proposals have been suggested for funding by the Peer Review Panel based on scientific excellence and by the Call Steering Committee based on budget availability. Proposals are presented in alphabetical order according to their acronym. Please refer to your national funding agency for further details. A list of the national contact representatives can be found here.

User-friendly fact sheets are available by clicking on the project titles below.

The supported projects are:

CeBioND: Cellular Bioenergetics in Neurodegenerative Diseases: A system-based pathway and target analysis
Coordinator: 
Maria Ankarcrona, Karolinska Institutet, Sweden
Partners:  
Jochen Prehn, RCSI Centre for Systems Medicine, Ireland
Paola Pizzo, University of Padua, Italy
David Park, University of Ottawa, Canada
Daniele Bano, DZNE, Bonn, Germany

Website: cebiond.org

CrossSeeds: Mechanisms of pathogenic protein cross-seeding in neurodegenerative disorders
Coordinator:
Hans-Ulrich Demuth, Fraunhofer Inst. for Cell Therapy & Immunology, Halle (Saale), Germany
Partners:
Steffen Roßner, University of Leipzig, Germany
Stephane Hunot, Brain & Spine Institute (ICM), Pierre et Marie Curie University – Inserm UMRS 1127, CNRS UMR 7225, Paris, France
Stephan von Hörsten, University of Erlangen, Germany
Jan G. Bjaalie, Institute of Basic Medical Sci., Univ. of Oslo, Norway

DAMNDPATHS: Elucidation of common transcriptional targets in vulnerable DopAmine, MotorNeuron and frontotemporal Dementia disease PATHwayS
Coordinator:
Eva Hedlund, Karolinska Institutet, Sweden
Partners:
Rosario Sanchez-Pernaute, Fundacion Inbiomed, Spain
Stefania Corti, University of Milano, Italy
Caroline Graff, Karolinska Institutet, Sweden
Rickard Sandberg, Karolinska Institutet, Sweden

Fly-SMALS: Common RNA-dependent pathways for motor neuron degeneration in spinocerebellar muscular atrophy and amyotrophic lateral sclerosis
Coordinator:
Jörg B. Schulz, University Medical Center, RWTH Aachen, Germany
Partners:
Aaron Voigt, Department of Neurology, University Medical Center, RWTH Aachen, Germany;
Florence Besse, Institute of Biology Valrose, Nice, France;
Margarida Gama-Carvalho, BioFIG, Faculty of Sciences, University of Lisbon, Portugal;
Javier De Las Rivas, Centro de Investigácion del Cáncer, Salamanca, Spain;
Joachim Weis, Institute of Neuropathology, University Medical Center, RWTH Aachen, Germany

InCure: Innate Immune Activation in Neurodegenerative Disease
Coordinator:
Michael T. Heneka, German Center for Neurodegenerative Disease and University of Bonn, Dept. of Neurology, Bonn, Germany
Partners:
Martin Korte, TU Braunschweig and Helmholtz Center for Infection Research (HZI), Braunschweig, Germany
Isabelle Le Ber, Morwena Latouche, Inserm, ICM UPMC Inserm UMR_S1127/CNRS UMR 7225, Paris, France
Rob Veerhuis, VU University medical center, Depts. of Clinical Chemistry and Psychiatry, Amsterdam, The Netherlands
Luigi Bubacco, Marina de Bernard, Dept. of Biology, University of Padova, Padova, Italy
Jesper Tegnér, Karolinska Institutet, Department of Medicine, Karolinska Institutet; Karolinska University Hospital, Center for Molecular Medicine, Stockholm, Sweden

MisingLink: Identification and structural characterization of the primordial cytotoxic conformers of the amyloidogenic cascade: Ideal prevention/diagnostic/therapeutic targets in neurodegeneration
Coordinator:
Mariano Carrión-Vázquez, CSIC (Cajal Institute),Spain
Partners:
Marek Cieplak, Polish Academy of Sciences, Poland
Damien Thompson, University of Limerick, Ireland

NeuroGeM: Identification of genes that modulate the severity of all neurodegenerative diseases
Coordinator:
Jörg Gsponer, University of British Columbia, Vancouver, Canada
Partners:
Jens Pahnke, University of Oslo, Norway
Olaf Riess, University of Tübingen, Germany
Eleonora Aronica, Academisch Medisch Centrum (AMC), Amsterdam, The Netherlands
Paul Pavlidis, University of British Columbia, Vancouver, Canada

NeuTARGETs: Targeting the propagation of pathogenic protein assemblies in neurodegenerative disease
Coordinator:
Chiara Zurzolo, Pasteur Institute, France
Partners:
Ronald Melki, LEBS CNRS UPR3082, 91198 Gif-sur-Yvette, France
Mathias Jucker, German Center for Neurodegenerative Diseases, Tübingen, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
Patrik Brundin/Sara Linse, Lund University, Sweden

PrPC&PDK1: The PrPC / PDK1 / TACE signaling axis at the cross-road of several aggregate-prone protein-associated neurodegenerative diseases
Coordinator:
Benoit Schneider, Univ. Paris Descartes / INSERM UMRS-1124, France
Partners:
Edward Fon, McGill University, Canada
Bart de Strooper, VIB Center for the Biology of Diseases, Belgium
Peter Heutink, DZNE, Germany
Xavier Roucou, Sherbrooke University, Canada
Vidar Gundersen, Institute of basic Medical Sciences, Norway

SynSpread: Role and mechanism of alpha-synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases
Coordinator:
Luis Pereira de Almeida, PhD, CNC – University of Coimbra, Portugal
Partners:
Jens C. Schwamborn, University of Luxembourg, Luxembourg
Martin Oheim, University Paris Descartes, PRES Sorbonne Paris, France
Ronan MT Fleming, University of Luxembourg, Luxembourg