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Martin Rossor is Professor of Clinical Neurology at the National Hospital for Neurology and Neurosurgery London and the NIHR National Director for Dementia Research.

Martin established a specialist cognitive disorders clinic which acts as a tertiary referral service for young onset and rare dementias. In order to support the clinic he established a telephone support service for patients “Counselling and Diagnosis in Dementia” (CANDID) which received the BUPA/Patient Association Award in 2000 and has since fostered the development of a number of patient support groups. As editor of JNNP (2004-2009) he introduced ‘patient choice’ in which an article of particular relevance was selected by a patient organisation representative for free online access.

As Director of DeNDRoN (Dementias and Neurodegenerative Diseases Clinical Research Network) he supported the NIHR vision of strong public and patient engagement and involvement through patient and carer representation on clinical study groups and involvement of patients and carers in portfolio development and grant writing. As NIHR National Director for Dementia Research he has launched, in collaboration with Alzheimer’s Society and Alzheimer’s Research UK a public portal – Join Dementia Research – for those interested in participating in research to register and be matched to relevant studies. He has worked closely with a number of charities and is a vice president of the UK Alzheimer’s Society.

Scientific Representative of Sanofi.

Dr. Thomas Rooney is Head of Translational Research for Neurodegenerative Diseases in the Aging Therapeutic Strategic Unit at Sanofi.  Dr. Rooney received his BSc in Pharmacology from the University of Glasgow, UK (1984) and his PhD in Neuropharmacology from the University of Leicester, UK (1987). He then moved to Thomas Jefferson University in Philadelphia, USA (1988-1998) where he was a postdoctoral fellow and then Assistant and Associate Professor in the Dept of Pathology and Cell Biology where he directed research focused on studying the organization of Ca2+ signalling at the subcellular level and the mechanisms by which growth factors and glutamate receptors regulate neuronal survival in the developing and adult brain. Since 1998, Dr Rooney has worked at Sanofi in Paris, France where he has headed research groups and drug development programmes focused on the treatment of Neurodegenerative Diseases, including Alzheimer’s and Parkinson’s Disease.  He also participates to several public-private collaborations and consortiums to accelerate R&D for Alzheimer’s and Parkinson’s Disease and contributed to the JPND industry consultations during the preparation of the JPND Strategic Research Agenda.

Main publications:

  1. Rooney, T., Sass, E., and Thomas, A.P. (1990). Agonist-induced cytosolic calcium oscillations originate from a specific locus in single hepatocytes. J. Biol. Chem. 265, 10792-10796.
  2. Zhang, F.X., Rubin, R., and Rooney, T. (1998). N-methyl-D-aspartate inhibits apoptosis through activation of phosphatidylinositol 3-kinase in cerebellar granule neurons: A role for insulin receptor substrate-1 in the neurotrophic action of N-methyl-D-aspartate and its inhibition by ethanol. J. Biol. Chem. 273, 26596-26602
  3. Itier, J.M., Ibanez, P., Mena, M.A., Abbas, N., Cohen-Salmon, C., Bohme, G.A., Laville, M., Pratt, J., Corti, O., Pradier, L., Ret, G., Joubert, C., Periquet, M., Araujo, F., Negroni, J., Casarejos, M.J., Canals, S., Solano, R., Serrano, A., Gallego, E., Sanchez, M., Denefle, P., Benavides, J., Tremp, G., Rooney, T, Brice, A., and Garcia de Yebenes, J.  (2003). Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum. Mol. Genet. 12, 2277-2291.
  4. Petiet, A., Santin, M., Bertrand, A., Wiggins, C.J., Petit, F., Houitte, D., Hantraye, P., Benavides, J., Debeir, T., Rooney, T., Dhenain, M. (2012). Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer’s transgenic mice. Neurobiol Aging. 33, 1533-1544.
  5. Santin, M., Debeir, T., Bridal, S.L., Rooney, T., Dhenain, M. (2013). Fast in vivo imaging of amyloid plaques using mu-MRI Gd-staining combined with ultrasound-induced blood brain barrier opening.  NeuroImage 79, 288–294.

Scientific Representative of Alzheimer Research UK.

Dr Eric Karran is a molecular biochemist by training, with a particular interest in enzymology and proteinases.  He has spent most of his career in the pharmaceutical industry, leading and managing multi-disciplinary drug discovery teams.   He has held Chief Scientific Officer and Vice President roles in a number of companies, including SmithKline Beecham (now GSK), Pfizer, Eli Lilly and Johnson and Johnson.  During his career he has led and participated in a number of academic/industry collaborations.  Eric has specialized in Neuroscience research, and particularly Alzheimer’s disease, for the past 20 years, participating in a number of projects that have led to late-stage clinical programmes.   Eric is a Visiting Professor in the Department for Human Genetics at the Catholic University of Leuven, Belgium, and an Honorary Senior Research Associate in the Department of Molecular Neuroscience at the Institute of Neurology, University College London.   He is currently the Director of Research for Alzheimer’s Research UK and has responsibility for setting the organization’s strategic scientific direction.

Main publications:

  1. Samer Matta, Kristof Van Kolen, Geert van den Bogaart, Raquel da Cunha, Wim Mandemakers, Katarzyna Miskiewicz, Pieter-Jan De Bock, Vanessa A. Morais, Sven Vilain, Dominik Haddad, Jef Swerts, Lucia Chavez, Giovanni Esposito, Guy Daneels, Eric Karran, Matthew Holt, Kris Gevaert, Dieder Moechars, Bart De Strooper and Patrik Verstreken. LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron,;75:1008-1021 (2012).
  2. Lucía Chávez-Gutiérrez, Leen Bammens, Iryna Benilova, Annelies Vandersteen, Manasi Benurwar, Marianne Borgers, Sam Lismont, Lujia Zhou, Simon Van Cleynenbreugel, Hermann Esselmann, Jens Wiltfang, Lutgarde Serneels, Eric Karran, Harrie Gijsen, Joost Schymkowitz, Frederic Rousseau, Kerensa Broersen, Bart De Strooper. The mechanism of gamma-Secretase dysfunction in familial Alzheimer disease. EMBO J., 31: 2261-2274: (2012)
  3. Iryna Benilova, Eric Karran, Bart De Strooper. The toxic ABeta oligomer and Alzheimer’s disease: an emperor in need of clothes. Nature Neuroscience, 15: 349-357 (2012).
  4. Eric Karran, Marc Mercken and Bart De Strooper. The amyloid cascade
    hypothesis for Alzheimer’s disease: an appraisal for the development of
    therapeutics. Nature Reviews Drug Discovery, 10: 698-712 (2011).
  5. L. Serneels, J. Van Biervliet, K. Craessaerts,  T. Dejaegere,  K. Horre, T. Van Houtvin,  H.Esselmann,  S. Paul, MK. Schafer,  O. Berezovska,  BT. Hyman B. Sprangers,  R.Sciot,  L. Moons, M. Jucker, Z. Yang,  PC. May, E. Karran J. Wiltfang,  R. D’Hooge,  B. De Strooper.  Gamma-secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer’s disease. Science, 324: 639-642, (2009).

Scientific Representative of Alzheimer Europe.

Charles Scerri received his PhD degree in 2004 from the University of Dundee in Scotland where he studied the involvement of nicotinic acetylcholine receptors in Alzheimer’s disease. He is currently a senior academic and group leader of the Alzheimer’s disease research group at the Department of Pathology, University of Malta. His major research interests include neuropharmacology in Alzheimer’s disease, societal impact of dementia, dementia policy and healthcare workforce development. He is the co-founder and general secretary of the Malta Dementia Society, honorary secretary of Alzheimer Europe and member of the Mediterranean Alzheimer Alliance. He is also a member of the EU Joint Progamme for Neurodegenerative Diseases Scientific Advisory Board and Early Detection and Timely Intervention in Dementia Group (INTERDEM). In 2009, he was appointed to Chair the Malta Dementia Strategy Group with the aim of devising a series of recommendations that would provide a strategic framework in order to deliver quality improvements in the management and care of dementia in the Maltese islands. In July of 2013, he was appointed as the National Focal Point on Dementia to advise the Maltese government on measurements that need to be adopted to make dementia a national healthcare priority. He has served on numerous organisational committees for international conferences on dementia and invited to deliver various lectures abroad.

Scientific Publications

  1. Scerri C, Stewart CA, Breen K, Balfour, DJK. The effects of chronic nicotine on spatial learning and bromodeoxyuridine incorportation into the dentate gyrus of the rat. Psychopharmacology (Berl) 2006;184:540-546.
  2. Gauci AJ, Caruana M, Giese A, Scerri C, Vassallo N. Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Abeta42 aggregates. J Alzheimers Dis 2011;27:767-779.
  3. Innes A, Abela S, Scerri C. The organisation of dementia care by families in Malta: The experiences of family caregivers. Dementia 2011;10:165-184.
  4. Scerri C (2012). Challenges of developing a dementia strategy: The case of Malta. In Anthea Innes, Fiona Kelly and Louise McCabe (Editors) Key issues in evolving dementia care: International theory-based policy and practice. London;Jessica Kingsley:150-172.
  5. Caruana M, Neuner J, Hogen T, Schmidt F, Kamp F, Scerri C, Giese A, Vassallo N. Polyphenolic compounds are novel neuroprotective agents against lipid membrane damage by alpha-synuclein in vitro. Biochim Biophys Acta 2012;1818:2502-2510.
  6. Scerri C, Stewart C, Balfour DJK, Breen K. Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats. Neurosci Lett 2012;514:22-26.
  7. Vassallo N, Scerri C. Mediterranean diet and dementia of the Alzheimer type. Curr Aging Sci. 2013;6:150-62.
  8. Caruana-Pulpan O, Scerri C. Practices in diagnosis, disclosure and pharmacotherapeutic management of dementia by general practitioners – a national survey. Aging Ment Health 2013;July 22:Epub ahead of print.

Scientific Representative of The Michael J. Fox Foundation for Parkinson’s Research.

Brian K. Fiske, PhD, is Vice President of Research Programs at The Michael J. Fox Foundation for Parkinson’s Research. In this role, he manages a team of research professionals who stay closely linked to the Parkinson’s research community in order to develop an aggressive and innovative agenda for accelerating research and drug development for Parkinson’s disease.
Dr. Fiske earned a Bachelor of Science degree in cellular and molecular biology from Texas A&M University and a Ph.D. in neuroscience from the University of Virginia. After completing postdoctoral research at Columbia University in New York, Brian spent several years as a science editor at the journal Nature Neuroscience. He joined the scientific staff of The Michael J. Fox Foundation for Parkinson’s Research in 2004.

Main publications:

1. Ross, O. A., et al. “Association of LRRK2 exonic variants with susceptibility to Parkinson’s disease: a case-control study.” Lancet Neurol. (2011).
2. Dorsey, E. R., et al. “Funding of Parkinson research from industry and US federal and foundation sources.” Mov Disord. 24.5 (2009): 731-37.
3. Fiske, B. K., M. A. Frasier, and T. B. Sherer. “Special focus section: gene therapy for Parkinson’s disease.” Exp.Neurol. 209.1 (2008): 28-29.
4. Elbaz, A., et al. “Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson’s disease: a large-scale international study.” Lancet Neurol. 5.11 (2006): 917-23.
5. Sherer, T. B., et al. “Crossroads in GDNF therapy for Parkinson’s disease.” Mov Disord. 21.2 (2006): 136-41.

 

Professor Myrra Vernooij-Dassen has been involved for many years in psychosocial dementia research. She has been trained as medical sociologist and was director of the Radboud Alzheimer Centre. She is affiliated to the Scientific Institute of Quality of Healthcare of Radboud University Medical Centre in Nijmegen, the Netherlands. She has performed a large body of research on quality of care and quality of life, especially in dementia and palliative care. She is currently engaged in translational and interdisciplinary dementia research. She supervised 32 PhDs. She published more than 250 (inter)national peer reviewed articles. She is chair of Interdem, a pan-European research network on detection and timely INTERvention in DEMentia.

Professor Vernooij-Dassen is visiting professor at the Gadjah Mada University in Yogyakarta, Indonesia and honorary visiting professor of the School of Health of Bradford University.  Myrra Vernooij received the Dutch royal honor to be promoted to officer in the order of Orange-Nassau. She received the IPA 2016 distinguished service to the field psychogeriatrics award.

Myrra Vernooij-Dassen reviewed several national dementia programmes in Europe. She is a member of the Expert Advisory Panel of Alzheimer Europe and of the Advisory Board of Alzheimer Netherlands.

 

Scientific Publications

5 selected publications

  • Spijker A, Wollersheim H, Teerenstra S, Graff M, Adang E, Verheij F,  Vernooij-Dassen M. Systematic care for caregivers of patients with dementia: a multicenter, cluster-randomized, controlled trial. Am J Geriatr Psychiatry. 2008 56(6) 1116-28.
  • Vernooij-Dassen M, Leatherman S, Olde Rikkert M. Quality of care in frail older persons: the fragile balance of receiving and giving. BMJ 2011 ;342:d403. doi: 10.1136/bmj.d403.
  • Leontjevas R, Gerritsen DL,Smalbrugge M, Teerenstra S, Vernooij-Dassen MJ, Koopmans RT. A structural multidisciplinary approach to depression management in nursing-home residents: a multicentre stepped-wedge cluster-randomised trial. Lancet 2013; 381:2255-64.
  • Vernooij-Dassen M, Moniz-Cook E. Raising the standard of applied dementia care research: addressing the implementation error. Aging Ment Health. 2014 May 12:1-6.
  • Vernooij-Dassen M, Jeon YH. Social health and dementia: the power of human capabilities. Int Psychogeriatr. 2016 May;28(5):701-3.

 

Bruno Dubois is currently Professor of Neurology at the Neurological Institute of the Salpétrière University Hospital at Paris, University Pierre et Marie Curie Paris 6. He is Director of the Behavioural Neurology Department and of the Dementia Research Center at the Hospital. He is also Director of the Research Unit Inserm U-610 of the ICM (Institut du Cerveau et de la Moelle Epinière) of the Hospital. He is coordinator of the National Reference Center on “Rare Dementias” and of the National Reference Center for “young-onset Alzheimer patients”. He is President of the Scientific Committee of France-Alzheimer and of IFRAD (International Fund Raising for Alzheimer’s disease), consultant for the Human Frontier Program and Expert of the French Agency of Drugs. He is a member of the European Alzheimer Disease Consortium (EADC). He has published on anatomical and biochemical studies on the central cholinergic systems in rodents and humans; on cognitive neuropharmacology; and on neuropsychology in patients with dementia, with special reference to memory and executive functions. He recently organized an Expert Consensus on the new criteria for Alzheimer’s disease and a Task Force on the new criteria for Parkinson’s disease dementia. He is principal or co-investigator of a number of research programs focusing on AD, prodromal AD and dementia in Parkinson’s disease.

Scientific publications

  1. Thiebaut de Schotten M, Urbanski M, Duffau H., Volle E, Levy R, Dubois B, Bartolomeo P. Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans. Science. 2005 Sep 30; 309(5744):2226-8.
  2. Pochon JB, Levy R, Fossati P, Lehericy S, Poline JB, Pillon B, Lebihan D, Dubois B. The neural system that bridges reward and cognition in humans: An fMRI study. PNAS, 2002, 99:5669-5674.
  3. Dubois B, Albert ML. Amnestic MCI or prodromal Alzheimer’s disease? Lancet Neurol. 2004 Apr;3(4):246-8
  4. Le Ber I, Guedj E, Gabelle A, Verpillat P, Volteau M, Thomas-Anterion C, Decousus M, Hannequin D, Vera P, Lacomblez L, Camuzat A, Didic M, Puel M, Lotterie JA, Golfier V, Bernard AM, Vercelletto M, Magne C, Sellal F, Namer I, Michel BF, Pasquier J, Salachas F, Bochet J, French Research network on FTD/FTD-MND, Brice A, Habert MO, Dubois B. Demographic, neurological and behavioural characteristics and brain perfusion SPECT in frontal variant of frontotemporal dementia. Brain, 2006 Nov; 129(Pt 11): 3051-65
  5. Dubois B, Feldman H, Jacova C, DeKosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O’Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ., Scheltens P. Research criteria for the Diagnosis of Alzheimer’s disease: revising of the NINCDS-ADRDA criteria. Lancet Neurol. 2007 Aug; 6(8):734-46.

Professor Bengt Winblad, MD, PhD has been involved in the field of dementia research for many years. He became MD 1971 and took his PhD in 1975 at the University of Umeå, Sweden, where he became a Docent in 1977 and Professor of Geriatric Medicine and Chief Physician in 1982. Bengt Winblad has since been a guest professor at the Department of Psychiatry in Frankfurt and honorary professor at Beijing University, Wuhan University and Shanghai University in China. Currently, he is working in Stockholm, Sweden as Professor of Geriatric Medicine at the Karolinska Institutet and is Chief Physician at Karolinska University in Huddinge.

Professor Winblad has been involved in numerous professional appointments and university activities. These have included being a member of the Advisory Committee for the Medical Research Council. He is co-chairing the European Alzheimer Disease Consortium (EADC) and presently chairing the Medical Scientific Advisory Panel of the Alzheimer Disease International (ADI). He is also a member of the Nobel Assembly for the Prize of Medicine and Physiology at the Karolinska Institutet. Professor Winblad is the Head of the KI-Alzheimer Disease Research Center in Huddinge including KASPAC (KI Dainippon Sumitomo Alzheimer Center), as well as the Director of the Swedish Brain Power research network.

Bengt Winblad’s research interests focus on the epidemiology, genetics and treatment of dementia conditions, especially Alzheimer’s disease. He has been presented with a number of awards for his contribution to this research area. He has taken the initiative regarding pharmaceutical treatment (memantine and later donepezil) of patients with severe Alzheimer’s disease. Professor Winblad has been a tutor for more than 150 PhD dissertations and has published more than 1000 original publications in the field of gerontology/geriatrics/dementia research.

Honours and Awards

  • 1997 The Royal Swedish Academy of Medical Sciences Award for Dementia Research
  • 1997 Norage Kabi Pharmacia Awards
  • 1997 The Alois Alzheimer Award
  • 1997 Honorary Professor, Beijing University of Medical Science
  • 2001 The Swedish Society of Medicine Award (Sandeborg’s price)
  • 2001 Swedish Medical Society (Thuréus prize)
  • 2001 Honorary Professor, Wuhan University of Medical Science
  • 2002 The Nordic Prize in Gerontology
  • 2002 Honorary Professor, University of Timisoara, Romania
  • 2005 IPA Recognition Award for Service to the Field of Psychogeriatrics
  • 2006 Honorary Professor, Jiao-Tong University, Shanghai
  • 2008 Award established in my name by the organisation International Conf in AD and related disorders (ICAD) “Khalid Iqbal and Bengt Winblad Lifetime Achievement Awards in AD” to be given out every year at ICAD conferences.

Five selected scientific publications

  • Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L. A pathogenic mutation for probable Alzheimer’s disease in the APP gene at the N-terminus of beta-amyloid. Nature Genetics. 1992, 1: 345-347
  • Winblad B, Poritis N. Memantine in severe dementia: Results of the 9M-best study (benefit and efficacy in severely demented patients during treatment with Memantine). Int J Ger Psych 1999: 14: 135-146
  • Winblad B, Palmer K, Kivipelto M. Jelic V, Fratiglioni L, Wahlund L-O, Nordberg A, Bäckman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, De Leon M, Decarli C, Erkinjuntti T, Giacobine E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, Van Duijn C, Visser PJ, Petersen R. Mild cognitive impairment: beyond controversies, towards a consensus: report of the International working group on mild cognitive impairment, J Internal Med 2004; 256; 240-246
  • Winblad B, Kilander L, Eriksson S, Minthon L, Båtsman S, Wetterholm A-L, Jansson-Blixt C, Haglund A, Donepezil in patients with severe Alzheimer´s disease: double-blind, parallel-group, placebo-controlled study. Lancet, 2006; 367(9516): 1057-65.5
  • Winblad B, Cummings J, Anderasen N, Grossberg G, Onofrj M, Sadowsky C, Zechner S, Nagel J, Lane R, A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer’s disease–rivastigmine patch versus capsule. Int J Geriatr Psych. 2007;22(5):456-67.

Dr Philip Scheltens studied at the Vrije Universiteit Amsterdam, Netherlands, gaining his MD in 1984, and PhD (magnetic resonance imaging in Alzheimer’s disease) in 1993. Clinical residencies in neurosurgery at the Municipal Hospital Slotervaart, and at the Vrije Universiteit Medical Centre, Amsterdam, as well as an associate professorship at Karolinska Institute, supported his academic development. Since 2000, Dr Scheltens is Professor of Cognitive Neurology and Director of the Alzheimer Center at the VU University Medical Center in Amsterdam. His main clinical and research interests are Alzheimer’s disease, vascular dementia, frontotemporal dementia, structural and functional imaging and CSF biomarkers.

Dr Scheltens is an active member of several societies including the Dutch Society for Neurology, the International Psychogeriatric Association, the American Academy of Neurology, the Alzheimer Imaging Consortium, the European Alzheimer’s Disease Consortium and the European College of Neuropsychopharmacology. He was associate editor of the Journal of Neurology, Neurosurgery and Psychiatry until 2010, book review editor of Alzheimer Disease and Associated Disorders as well as member of the editorial boards of Dementia and Geriatric Cognitive Disorders, Journal of NeuroImaging and International Journal of Geriatric Psychiatry, and acts as an ad hoc reviewer of scientific articles for, amongst others, The Lancet Neurology, Stroke, Journal of Neurology, Neurology, JNNP, Brain, Annals of Neurology and Science. He is a member of the scientific advisory panel of the French Plan Alzheimer, member of the Scientific advisory board of the Joint Programming Neurodegeneration and treasurer of the International Society for Vascular Behavioural and Cognitive Disorders (Vas-Cog).

Honours and Awards

  • 1998 Medaille d’Or Universiteit Lille.
  • 1997-98 Visiting Professor Karolinska Institute, Stockholm, Zweden.
  • 1998-99 Visiting Professor Institute for the Health of the Elderly, Newcastle upon Tyne, UK
  • 2000 Membre d’honeur a titre etranger de Societe Francaise de Neurologie.
  • 2004 Visiting Professor, University of British Columbia, Canada
  • 2008-2013 Honorary Professor of Neurology, University College of London, Institute of Neurology, Queen Square

Scientific publications

More than 406 publications in peer reviewed journals, >550 scientific abstracts and many chapters in national and international books, as well as co-editor of the book Magnetic Resonance in Dementia (Springer) 2002 and co-editor of the book Clinical applications of fMRI (Oxford University Press).

Selected recent publications

  1. Frisoni GB, Fox NC, Jack CR Jr, Scheltens P, Thompson PM. The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol 2010;6:67-77.
  2. Scheltens P, Kamphuis PJGH, Verhey FRJ, Olde Rikkert MGM, Wurtman RJ, Wilkinson D, Twisk JWR, Kurz A. Efficacy of a medical food in mild Alzheimer’s disease: a randomized, controlled trial. Alzheimers Dement 2010;6:1-10
  3. Bouwman FH, Schoonenboom NSM, Verwey NA, van Elk EJ, Kok A, Blankenstein MA, Scheltens P, van der Flier WM. CSF biomarker levels in early and late onset Alzheimer’s disease. Neurobiol Aging 2009;30:1895-1901.
  4. Goos JDC, Kester MI, Barkhof F, Klein M, Blankenstein MA, Scheltens P, van der Flier WM. Patients with Alzheimer disease with multiple microbleeds. Relation with cerebrospinal fluid biomarkers and cognition. Stroke 2009;40:3455-3460.
  5. Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O’Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Pantoni L, on behalf of the LADIS Study Group. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ 2009;339:b2477

Stefano F. Cappa received his M.D. at the University of Milano, in which he completed his neurology training. He has held assistant professor and associate professor positions in Neurology and Neurological Rehabilitation at the University of Brescia. Since 1999 he is Professor of Neuropsychology at the Vita Salute S. Raffaele University in Milano, Italy and, from Nov 2000 to Nov 2009, Dean of Psychology. He is also Director of the Neurology Department of S. Raffaele Turro Hospital, Milano, Italy. He has spent research periods at Boston University, at the Massachusetts Institute of Technology, at University of California San Diego, at the Medical Research Council Cyclotron Unit of Hammersmith Hospital in London and at the Max Planck Institut for Cognitive Neuroscience in Leipzig.

His main research interests are:

  • the investigations in linguistic aspects of aphasia, with a special emphasis on the neurological correlates of specific aspects of language impairment;
  • Alzheimer’s disease and dementia;
  • diagnosis, unusual neuropsychological features, and cognitive studies of memory disorders in dementia;
  • the application of functional imaging methods (positron emission tomography, functional magnetic resonance) to the study of cognitive function (in particular, language and semantic memory);
  • cognitive studies of disorders of space cognition and exploration, their neurological correlates and the variables affecting recovery.

Scientific publications

He has published more than 200 papers in refereed journals, as well as several books and book chapters, and has served in many Editorial Boards.

  1. Garibotto V, Borroni B, Kalbe E, Herholz K, Salmon E, Holtoff V, Sorbi S, Cappa SF, Padovani A, Fazio F, Perani D. Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence. Neurology. 2008 Oct 21;71(17):1342-9.
  2. Gorno-Tempini ML, Brambati SM, Ginex V, Ogar J, Dronkers NF, Marcone A Perani D, Garibotto V, Cappa SF, Miller BL. The logopenic/phonological variant of primary progressive aphasia. Neurology. 2008 Oct 14;71(16):1227-34.
  3. Nicola Canessa, Francesca Borgo, Stefano F. Cappa, Daniela Perani, Andrea Falini, Giovanni Buccino, Marco Tettamanti and Tim Shallice The different neural correlates of action and functional knowledge in semantic memory: an fMRI study, Cerebral Cortex 2007 Jul 9.
  4. Cotelli, M., anenti R., Cappa SF, Geroldi C, Zanetti Rossini PM, Miniassi C Transcranial magnetic stimulation improves action naming in Alzheimer’s patients. Archives of Neurology 63. 1602-1604
  5. Rosa Manenti, Claudia Repetto, Simone Bentrovato, Elizabeth Bates and Stefano Cappa The effects of aging and Alzheimer’s Disease on semantic and gender priming Brain 127, 2299-2306