Stefano F. Cappa received his M.D. at the University of Milano, in which he completed his neurology training. He has held assistant professor and associate professor positions in Neurology and Neurological Rehabilitation at the University of Brescia. Since 1999 he is Professor of Neuropsychology at the Vita Salute S. Raffaele University in Milano, Italy and, from Nov 2000 to Nov 2009, Dean of Psychology. He is also Director of the Neurology Department of S. Raffaele Turro Hospital, Milano, Italy. He has spent research periods at Boston University, at the Massachusetts Institute of Technology, at University of California San Diego, at the Medical Research Council Cyclotron Unit of Hammersmith Hospital in London and at the Max Planck Institut for Cognitive Neuroscience in Leipzig.

His main research interests are:

  • the investigations in linguistic aspects of aphasia, with a special emphasis on the neurological correlates of specific aspects of language impairment;
  • Alzheimer’s disease and dementia;
  • diagnosis, unusual neuropsychological features, and cognitive studies of memory disorders in dementia;
  • the application of functional imaging methods (positron emission tomography, functional magnetic resonance) to the study of cognitive function (in particular, language and semantic memory);
  • cognitive studies of disorders of space cognition and exploration, their neurological correlates and the variables affecting recovery.

Scientific publications

He has published more than 200 papers in refereed journals, as well as several books and book chapters, and has served in many Editorial Boards.

  1. Garibotto V, Borroni B, Kalbe E, Herholz K, Salmon E, Holtoff V, Sorbi S, Cappa SF, Padovani A, Fazio F, Perani D. Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence. Neurology. 2008 Oct 21;71(17):1342-9.
  2. Gorno-Tempini ML, Brambati SM, Ginex V, Ogar J, Dronkers NF, Marcone A Perani D, Garibotto V, Cappa SF, Miller BL. The logopenic/phonological variant of primary progressive aphasia. Neurology. 2008 Oct 14;71(16):1227-34.
  3. Nicola Canessa, Francesca Borgo, Stefano F. Cappa, Daniela Perani, Andrea Falini, Giovanni Buccino, Marco Tettamanti and Tim Shallice The different neural correlates of action and functional knowledge in semantic memory: an fMRI study, Cerebral Cortex 2007 Jul 9.
  4. Cotelli, M., anenti R., Cappa SF, Geroldi C, Zanetti Rossini PM, Miniassi C Transcranial magnetic stimulation improves action naming in Alzheimer’s patients. Archives of Neurology 63. 1602-1604
  5. Rosa Manenti, Claudia Repetto, Simone Bentrovato, Elizabeth Bates and Stefano Cappa The effects of aging and Alzheimer’s Disease on semantic and gender priming Brain 127, 2299-2306

Specialist in Clinical Neurology and Preventive Medicine & Public Health, Jesús de Pedro Cuesta holds Spanish and Swedish citizenship and a Spanish and Swedish board-certificates in neurology. He was formally trained at the Karolinska Institute in social medicine and obtained a PhD degree in Health Services Research in 1986. For 1986-2005, he headed the Neuroepidemiology Unit at Huddinge University Hospital (Division of Neurology, Karolinska Institute). From 1994 to 2009 he was responsible for the Spanish National CJD Register. Major interest fields are epidemiology and services research on neurodegenerations including prion disorders and neuro-autoimmune diseases. Present position, since 1991: Head of the Department of Applied Epidemiology at the National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. He has published approximately 150 epidemiological and health-services research papers in international peer-reviewed journals.

Scientific publications

  1. Gunnarsson LG, Lygner PE, de Pedro-Cuesta J, Veiga-Cabo J. An epidemic-like cluster of motor neuron disease in the County of Skaraborg, Sweden, 1973-1984. Neuroepidemiology 1996:15:142-152
  2. de Pedro-Cuesta J, Petersen IJ, Stawiarz L, Gudmundsson G, Gudmundsson G, Almazán J, Tulinius H, Johansson H. High levodopa use in periodically, time-clustered, Icelandic birth cohorts. A vestige of Parkinsonism etiology?. Acta Neurol Scand 1995:91:79-88
  3. de Pedro-Cuesta J, Gudmundssson G, Abraira V, Gudmundsson G, Almazán J, Veiga J, Tulinius H, Löve A. Whooping cough and Parkinson´s Disease. Int J Epidemiology. 1996:25:1301-1311
  4. I Zerr, M. Pocchiari, S Collins, JP Brandel, J. de Pedro Cuesta, RSG Knight, Bernheimer H, Cardone F, Delasnerie-Laupretre N, Cuadrado Corrales N, Ladogana A, Bodemer M, Fletcher A, Awan T, Ruiz Bremon A, Budka H, LaplancheJL, Will RG, Poser S. Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt-Jakob disease. Neurology 2000;55:811-5.
  5. Jin YP, de Pedro-Cuesta J, Söderström M. Predicting Multiple Sclerosis at Optic Neuritis Onset. Multiple Sclerosis 2003; 9: 135-141
  6. A Ladogana, M Puopolo, E Croes, H Budka, C Jarius, S Collins, C Masters, T Sutcliffe, A Guilivi, A Alperovitch, N Delasniere-Laupretre, J-P Brandel, S Poser, H Kretschmar, E Mitrova, J de Pedro Cuesta, P. Martinez-Martín, M Glatzel, A Aguzzi, R Knight, H Ward, M Pocchiari, C van Duijn, RG Will, I Zerr . Descriptive Epidemiology of Creutzfeldt-Jakob disease 1993-2000): The EUROCJD Collaborative study. Neurology 2005,65:1586-9129.
  7. de Pedro-Cuesta J, Bleda MJ, Rabano A, Cruz M, Laursen H, Molbak K, Siden A; on behalf of the EUROSURGYCJD Research Group. Classification of surgical procedures for epidemiologic assessment of sporadic Creutzfeldt-Jakob Disease transmission by surgery. Eur J Epidemiol. 2006;21:595-604.
  8. de Pedro-Cuesta J, Markus GlatzeL M, Almazan J, Stoeck K, Mellina V, Puopolo M, Pocchiari M, Zerr I, Kretzschmar HA, Brandel JP, Delasnerie-Laupretre N, Alperovitch A, van Duijn C, Sanchez-Juan P, Collins S, Lewis V, Jansen GH, Coulthart MB, Gelpi E, Budka H and Mitrova E. Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002. BMC Public Health 2006,
  9. Mahillo-Fernandez I, De Pedro Cuesta J, Bleda MJ, Cruz M, Mølbak K, Laursen H, Falkenhorst G, Martínez-Martín P, Siden Å. Surgery and risk of sporadic Creutzfeldt-Jakob disease in Denmark and Sweden: registry-based case-control studies. Neuroepidemiology, 2008, 2008; 31:229-40

Martin Knapp is Professor of Social Policy and Co-Director of LSE Health and Social Care at the London School of Economics. He is also Professor of Health Economics and Director of the Centre for the Economics of Mental Health at the Institute of Psychiatry, King’s College London. Since 2009, he has been Director of the NHIR School for Social Care Research in England.

For many years, Martin has been working in the fields of long-term care, mental health policy and practice, and health and social care policy more generally. Current activities include economic evaluations of a wide range of treatments and other interventions; studies of mental illness prevention and mental health promotion; examination of policies aimed at extending choice to patients and service users; and analyses of financing arrangements in health and social care systems.

He has been adviser on mental health and social care policy to many UK government departments and agencies (including the Prime Minister’s Strategy Unit, Department of Health, Department for International Development, Department for Work and Pensions, Department for Industry, Universities and Science), various quasi-governmental bodies, research charities, World Health Organization, World Bank and European Commission. From 2006 to 2007, he was Specialist Adviser to the House of Lords EU Select Committee inquiry on mental health.

Scientific publications

Publications include more than 350 articles in peer-review journals, about 150 chapters in edited volumes, 15 books and 4 edited books. Recent publications include:

  1. Adelina Comas-Hererra, Sarah Northey, Raphael Wittenberg, Martin Knapp, Sarmishtha Bhattacharyya and Alistair Burns (2010) Investigating future scenarios about the future prevalence and costs of cognitive impairment in older people, International Psychogeriatrics, forthcoming.
  2. Jose-Luis Fernandez, Julien Forder, Martin Knapp, (2010) Long-term care, in Peter Smith and Sherry Glied (editors) The Oxford Handbook of Health Economics, Oxford University Press, Oxford, forthcoming.
  3. Martin Knapp (2009) Mental well-being of older people: making an economic case (editorial), Australian eJournal for the Advancement of Mental Health, 8(2), 5pp.
  4. Paul McCrone, Sujith Dhanasiri, Anita Patel, Martin Knapp, Simon Lawton-Smith (2008) Paying the Price: The Cost of Mental Health Care in England to 2026, King’s Fund, London.
  5. Martin Knapp and Ami Somani (2008) Long-term care, organization and financing, in Harald Kristian Heggenhougen and Stella Quah (Editors) International Encyclopaedia of Public Health, volume 4, pages 133-141, Elsevier, New York.
  6. Martin Knapp, David McDaid, Elias Mossialos and Graham Thornicroft, editors (2007) Mental Health Policy and Practice across Europe, Open University Press, Buckingham.
  7. Adelina Comas-Herrera, Raphael Wittenberg, Linda Pickard and Martin Knapp (2007) Cognitive impairment in older people: the implications for future demand for long-term care services and their costs, International Journal of Geriatric Psychiatry, 22, 1037-1045.
  8. Robert J Howard, Edmund Juszczak, Clive Ballard, Peter Bentham, Richard Brown, Roger Bullock, Alistair Burns, Clive Holmes, Robin Jacoby, Tony Johnson, Martin Knapp, James Lindesay, John O’Brien, Gordon Wilcock, Cornelius Katona, Roy Jones, Julia DeCesare, Michaela Rodger and the CALM-AD Trial Group* (2007) Donepezil for the treatment of agitation in Alzheimer’s disease, New England Journal of Medicine, 357, 1382-1392.
  9. Martin Knapp (2007) Economic outcomes and levers: impacts for individuals and society, International Psychogeriatrics, 19, 483-495.
  10. Martin Knapp, Lene Thorgrimsen, Anita Patel, Aimee Spector, Angela Hallam, Bob Woods and Martin Orrell (2006) Cognitive stimulation therapy for people with dementia: cost-effectiveness analysis, British Journal of Psychiatry, 188, 574-580.

Professor John Hardy is a geneticist and molecular biologist whose research interests focus on neurological disease. Dr. Hardy received his B.Sc. (Hons) degree from the University of Leeds, UK (1976) and his Ph.D. from Imperial College, London, UK where he studied dopamine and amino acid neuropharmacology. Dr. Hardy received his postdoctoral training at the MRC Neuropathogenesis Unit in Newcastle upon Tyne, UK and then further postdoctoral work at the Swedish Brain Bank in Umeå, Sweden where he started to work on Alzheimer’s disease.

He became Assistant Professor of Biochemistry at St. Mary’s Hospital, Imperial College, London in 1985 and initiated genetic studies of Alzheimer’s disease whilst there. He was appointed Associate Professor in 1989 and then took the Pfeiffer Endowed Chair of Alzheimer’s Research at the University of South Florida, in Tampa in 1992. In 1996 he moved to the Mayo Clinic in Jacksonville, Florida, as Consultant and Professor of Neuroscience. He became Chair of Neuroscience in 2000 and moved to NIA as Chief of the Laboratory of Neurogenetics in 2001. He won the MetLife, the Allied Signal and the Potamkin Prize for his work in describing the first genetic mutations, in the amyloid gene in Alzheimer’s disease, in 1991. From 2001 to 2007, he was Head of the Neurogenetics Section, National Institute of Ageing, Bethesda, USA.

In 2007, he took up the Chair of Molecular Biology of Neurological Disease at the UCL Institute of Neurology. With over 23,000 citations, Prof Hardy is the most cited Alzheimer’s disease researcher in the UK (5th internationally). In recognition of his exceptional contributions to science, he was elected a Fellow of the Royal Society in 2009.

Honours and Awards

  • 1991 Peter Debje Prize, University of Limburg, Belgium, For Alzheimer’s Research
  • 1992 IPSEN Prize for Research into Alzheimer’s Disease
  • 1993 Potamkin Prize (American Academy of Neurology) for Alzheimer’s Research
  • 1995 Allied Signal Prize for Research into Aging
  • 1995 MetLife Prize for Research into Alzheimer’s disease
  • 2002 Kaul Prize for Research into Alzheimer’s disease
  • 2008 Anne Marie Oprecht International Prize for Research in Parkinson’s Disease
  • 2008 Elected to membership of the Academy of Medical Sciences
  • 2008 Honorary MD, University of Umea, Sweden
  • 2009 Elected to the Royal Society

Scientific publications

  1. Van Deerlin VM, Sleiman PMA, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP43 inclusions Nature Genetics 2010; 42: 234-U34.
  2. Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nature Genetics 2009;41:088-U61.
  3. Simon-Sanchez J, Schulte C, Bras JM; et al. Genome-wide association study reveals genetic risk underlying Parkinson’s disease. Nature Genetics 2009;41:1308-U68.
  4. Hardy J, Singleton A. Genomewide Association Studies and Human Disease. New England Journal of Medicine 2009;360:1759-1768.
  5. Nalls MA, Guerreiro RJ, Simon-Sanchez J, Bras JT, Traynor BJ, Gibbs JR, Launer L, Hardy J, Singleton AB. Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer’s disease. Neurogenetics. 2009;10:183-90.
  6. Zody MC, Jiang Z, Fung HC, et al. Evolutionary toggling of the MAPT 17q21.31 inversion region. Nature Genetics 2008;40:1076-1083.
  7. Jakobsson M, Scholz SW, Scheet P, et al. Genotype, haplotype and copy-number variation in worldwide human populations Nature 2008;451:998-1003.
  8. Matarin M, Simon-Sanchez J, Fung HC, et al. Structural genomic variation in ischemic stroke. Neurogenetics 2008;9:101-108.
  9. Myers AJ, Gibbs R, Webster J, Rohrer K, Zhao A, Marlowe L, Kaleem M, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu- Lince D, Coon KD, Craig DW, Pearson JV, Holmans P, Heward CB, Reiman EM, Stephan D, Hardy J. A survey of genetic cortical gene expression. Nature Genetics 2007;39:1494-9.
  10. Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA. GAB2 alleles modify Alzheimer’s risk in APOE epsilon4 carriers. Neuron. 2007;54:713-20.