The Accelerating Medicines Partnership (AMP) is a new venture between the US National Institutes for Health (NIH), 10 bio-pharmaceutical companies and several non-profit organizations to transform the current model for developing new diagnostics and treatments by jointly identifying and validating promising biological targets of disease. The ultimate goal is to increase the number of new diagnostics and therapies for patients and reduce the time and cost of developing them.

AMP will begin with three to five year pilot projects in three disease areas: Alzheimer’s Disease, type 2 diabetes and autoimmune disorders of rheumatoid arthritis and systemic lupus erythematosus (lupus).

Focus on Alzheimer’s Disease:

For the project on biomarkers, the tau imaging and EEG data will be released in year two, as baseline data become available. Final data from the randomized, blinded trials will be added after the end of the five year studies, and will include both the imaging data and data from blood and spinal fluid biomarker studies. For the network analysis project, each individual project will generate several network models of late onset AD (LOAD) and will identify key drivers of disease pathogenesis by the end of year three. Years four and five will be largely dedicated to validating the novel targets and refining the network models of LOAD, including screening novel compounds or drugs already in use for other conditions that possess the ability to modulate the likely targets.

The budget for Alzheimer’s Disease over 5 years is $129.5 Million (Total Project Funding)

Source:  NIH (USA)

 

Links

Link to AMP on NIH website
Link to Alzheimer's project on NIH website

февруари 12, 2015