The aim of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) project is to identify the neural mechanisms underpinning successful cognitive ageing. The study recruitment participants over 18 from resident within Cambridge City and used epidemiological, behavioural, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age. A major aim of the research programme is to understand the nature of brain-cognition relationships across the lifespan, and to highlight the importance of abilities that are maintained into old age.

This population study was not designed to have repeated measures for each participant, but rather as one extended and comprehensive study visit that took place over 3 stages.

For the Esprit study, 1863 non-institutionalized persons aged 65 years and over were randomly recruited in 1999 from the Montpellier district electoral rolls, and re-examined 6-times at 2-3 yearly intervals. Objectives:

1) To determine current and lifetime prevalence as well as incidence of psychiatric disorder in the elderly;
2) to determine the risk factors for these disorders, their relative weight and interactions;
3) to study clinical heterogeneity;
4) to estimate the probability of transition towards a subsyndromic state or a given pathology;
5) to elaborate predictive etiological models.

The ADC was setup in 2004 by including all patients who come to the Alzheimer Center for diagnostic work up and who consent to give all data, collected as part of the routine diagnostic work up, for research. The aim is and was to facilitate research into new and existing biomarkers in the broadest sense, to establish diagnostic, prognostic and theragnostic values and further insight into the pathogenesis of neurodegenerative dementias. The data are collected on a weekly basis and consist of baseline data and annual follow up data. Since it is conception it has grown into one of the largest clinical databases in the dementia field. More info on setup, characteristics and data collection can be found in van der Flier WM, Pijnenburg YA, Prins N, Lemstra AW, Bouwman FH, Teunissen CE, van Berckel BN, Stam CJ, Barkhof F, Visser PJ, van Egmond E, Scheltens P.

Optimizing patient care and research: the Amsterdam Dementia Cohort. J Alzheimers Dis. 2014;41(1):313-27. doi: 10.3233/JAD-132306. PubMed PMID: 24614907.

Last Update 21/09/2017