The ZARADEMP project (ZARAgoza DEMentia
DEPression project) was designed as a longitudinal,
community-based study to examine the incidence
of dementia and the risk factors in incident cases of
dementia. It was carried out in Zaragoza, a typical,
large city in Spain, with an important proportion
of inhabitants coming from surrounding rural
areas (12). A stratified random sample of individuals
55 years of age and older, with proportional
allocation by age and sex, drawn from the eligible
individuals (n = 157 787) in the Spanish official
census lists of 1991, was invited to participate in
the baseline examination.
Archives
The Concord Health and Ageing in Men Project (CHAMP) is one of the worlds largest and most comprehensive study of the health of older men ever conducted anywhere in the world. CHAMP involves 1705 men aged 70 years and older recruited from the community living near Concord Hospital in Sydneys inner west. Subjects were recruited during 2005 and 2006 and subjects were re-assessed after two, five and nine years. A 14 year follow-up assessment (wave 5) is planned for 2019. Clinical dementia assessment was done at baseline but not in waves 2, 3, and 4. Clinical dementia assessment will be included in wave 5.
The study is particularly concerned with cognitive impairment and dementia; falls, fractures and osteoporosis; and urinary problems.
The West of Scotland Twenty-07 Study: ‘Health in the community’ was set up in 1986 in order to investigate the reasons for differences in health by socio-economic circumstances, gender, the place where people live, age, ethnic group and family type.
The basic design of the Study involved recruiting three cohorts (groups) of volunteers, each group born twenty years apart. Members of the oldest cohort were born around 1932, those in the middle cohort were born in 1952, and those in the youngest cohort were born in 1972. A total of 4,510 people agreed to take part, and have been followed for 20 years. The final wave of data collection was completed in 2008. This means that when the Study began (1987/8) participants were 15, 35 or 55 years old, and by the end of the Study (2007/8), participants were 35, 55 and 75 years old.
The data collected are extensive and include self-reported mental and physical health (including chronic conditions, medications, disabilities); physical measures; biomarkers; cognition; life circumstances (including employment, housing, family); health behaviours; beliefs, attitudes and values. The cohort is being followed up for mortality using linkage to national records. Any data on neurodegenerative disease are from self-reported health and / or death certificates.
A full description of the cohort profile is available in the following publication: Cohort Profile: West of Scotland 20-07 study: health in the community. International Journal of Epidemiology 2009;38:1215-23
The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older. Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. Measurements included traditional risk factors such as blood pressure and lipids as well as measures of subclinical disease, including echocardiography of the heart, carotid ultrasound, and cranial magnetic-resonance imaging (MRI). At six month intervals between clinic visits, and once clinic visits ended, participants were contacted by phone to ascertain hospitalizations and health status.
Information on dementia comes from two Ancillary Studies. The CHS Cognition Study (Dr. Lewis Kuller, PI) included 3608 participants who had an MRI in 1992-94 and who were followed for dementia through 1999. A follow-up study was done at the Pittsburgh field center that included 532 participants followed through 2013 (Dr. Oscar Lopez,PI).
JSTAR project researchers aimed to construct a world-class longitudinal dataset on middle-aged and elderly Japanese persons to enable researchers worldwide to perform scientific investigation on aging and retirement from an international perspective. Despite the rapid aging of the Japanese population, no statistical survey that could properly capture the diversity of the elderly population from various viewpoints had been carried out in Japan until recently. RIETI, Hitotsubashi University jointly launched a comprehensive survey of elderly people in 2007 to collect panel data on their lives and health, with the University of Tokyo joining from 2009 onward.
The 2009 JSTAR survey includes a follow-up survey of the respondents to the 2007 survey and an initial survey of elderly people in two additional municipalities, i.e., Tosu in Saga Prefecture and Naha in Okinawa Prefecture, whereas the 2011 JSTAR Survey includes follow-up surveys of the respondents to the 2007 and 2009 surveys plus an initial survey of elderly people in three additional municipalities, Tondabayashi, Chofu, and Hiroshima
The MemoVie cohort study aims to investigate the living conditions or risk factors under which the normal cognitive capacities of the senior population in Luxembourg (? 65?year-old) evolve (1) to mild cognitive impairment (MCI) ? transitory non-clinical stage ? and (2) to AD. Identifying MCI and AD predictors undeniably constitutes a challenge in public health in that it would allow interventions which could protect or delay the occurrence of cognitive disorders in elderly people. In addition, the MemoVie study sets out to generate hitherto unavailable data, and a comprehensive view of the elderly population in the country.
A 1-year follow-up was included in the original design of the study. The enrolled participants have been followed-up.
The Uppsala Birth Cohort Multigeneration Study (UBCoS) started in 2005 when we were first able to combine existing data on a representative and well-defined cohort of 14,192 males and females born in Uppsala from 1915-1929 (the Uppsala Birth Cohort: UBCoS) with information on descendants of the original cohort members obtained from routine registers.
In 2007-2011, the study was further developed by additional data collection in school archives and records from Census 1930 and the period of follow-up was extended till end of year 2009.
The study is unique in investigating intergenerational effects as “forward in time” processes, starting at the beginning of the last century (i.e. well before any of the routine registers were in place). Intergenerational associations can be currently investigated in more than 140,000 study subjects from families spanning up to five generations, including the 14,192 original cohort members, their 22,559 children, 38,771 grandchildren and 25,471 great grandchildren born up to 2009.
The Kungsholmen Project is a longitudinal population-based study on ageing and dementia, carried out by the Stockholm Gerontology Research Center in collaboration with Aging Research Center (ARC), Karolinska Institutet.
The project, which started in 1987, has gathered a 12-year long database and offers information on aging from a multidisciplinary perspective. All persons that were born before 1913 and lived in the Kungsholmen district of Stockholm, were invited to participate (a total of 2368 persons on October 1st, 1987, including both community-dwelling and institutionalized persons). Later, the research additionally included all 90+ old subjects living in the St. Göran parish, an adjacent geographical area. The baseline phase and four follow-ups have been completed, with the last phase concluding in the summer of 2000. Time 1 was the only measurement occasion when a two-phase study design was adopted, with an extensive clinical examination performed after a screening phase. At every other occasion, all participants were interviewed by nurses, clinically examined by physicians, and assessed by psychologists.
In 1999 the Swedish Ministry for Social Affairs promoted and supported a national project aimed at monitoring and evaluating the care-of-the-elderly system in Sweden. To achieve these aims, four longitudinal individual-based data collection describing the aging process and encompassing the care system as whole, has been initiated. This project was named The Swedish National study on Aging and Care (SNAC).
SNAC-K is conducted by the Stockholm Gerontology Research Center in collaboration with Aging Research Center (ARC), Karolinska Institutet.
SNAC-K includes two studies: SNAC-K population study and SNAC-K care system study.
Convenience sample of centenarians, their siblings, offspring, spouses and a control sample consisting of people born around same time as offspring but who do not have parents surviving beyond average life expectancy for their birth cohort. Age range 40-119 years, with ~2500 centenarians in the sample including 600 semi-supercentenarians (ages 105-109) and 200 supercentenarians (ages 110+ years).
We collect the below listed data at enrolment and then collect vital status, hospitalization, changes in meds and diagnoses, cognitive function (TICS) and physical function (IADS, ADL) over the phone, annually. Local subjects are asked to undergo annual detailed cognitive function testing in person with ultimately, brain donation. Blood sample collected at enrolment for DNA, RNA and plasma for biomarkers and storage.
Study is open to collaborations. Please contact Dr. Perls