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The ZARADEMP project (ZARAgoza DEMentia
DEPression project) was designed as a longitudinal,
community-based study to examine the incidence
of dementia and the risk factors in incident cases of
dementia. It was carried out in Zaragoza, a typical,
large city in Spain, with an important proportion
of inhabitants coming from surrounding rural
areas (12). A stratified random sample of individuals
55 years of age and older, with proportional
allocation by age and sex, drawn from the eligible
individuals (n = 157 787) in the Spanish official
census lists of 1991, was invited to participate in
the baseline examination.

The Atherosclerosis Risk in Communities Study (ARIC) is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date. Since 2011 a large ancillary study, the ARIC Neurocognitive Study (ARIC-NCS) has been assessing neurocognitive status and adjudicating possible cases of dementia.

Four ARIC field centers each randomly selected and recruited a cohort sample of approximately 4,000 individuals aged 45-64 from a defined population in their community. A total of 15,792 participants received an extensive baseline examination (visit 1, 1987-1989), including medical, social, and demographic data collection. Subsequent examinations occurred in 1990-92 (visit 2), 1993-95 (visit 3), 1996-98 (visit 4), 2011-2013 (visit 5) and 2016-2017 (visit 6). Visit 7 (2018-2019) is currently in progress. Follow-up occurs annually (semi-annually since 2012) by telephone to maintain contact with participants and to assess health status of the cohort.

The 1970 British Cohort Study (BCS70) follows the lives of more than 17,000 people born in England, Scotland and Wales in a single week of 1970. Over the course of cohort members lives, the BCS70 has collected information on health, physical, educational and social development, and economic circumstances among other factors.

Recruitment Period: 2004
Sample size at start or planned sample size if still recruiting: 16,122 (15,770 households included at Sweep 1; 352 ethnic boost interviews added at Sweep 4)
Estimated current sample size: 15,629
Age at recruitment: 13-14

Abstract
Next Steps (previously known as the Longitudinal Study of Young People in England – LSYPE) is a major innovative cohort study of young people. The study began in 2004 and included all young people in Year 9, aged between 13 and 14, who attended state and independent schools in England.

Next Steps is one of the main information sources for the formation and appraisal of policies relating to young people and will continue to be so for at least the next 10 years. The baseline data will be used to monitor the progress of the cohort group, evaluate the success of policies aimed at this group and provide an evidence base for further policy development. The study brings together data from a wide range of sources and reflects the variety of influences on learning and progression.

Following the initial survey at age 13-14, the cohort members were visited every year until 2010, when they were age 19-20. Young people were interviewed along with their parents up to sweep 4 (age 17).

The most recent survey took place in 2015/16, when the cohort members were 25 years old. It maintained the strong focus on education, but the content was broadened to become a more multi-disciplinary research resource. Data was collected about cohort members’ housing and family life, employment and economic circumstances, education and job training, physical and emotional health, and identity and participation. A wide range of administrative data linkage consents were collected in the domains of health, education, economics and criminal behaviour.

The Nurses’ Health Study II (NHS II) was established by Dr. Walter Willett and colleagues in 1989 with funding from the National Institutes of Health to study oral contraceptives, diet, and lifestyle risk factors in a population younger than the original NHS cohort.

Why a new cohort of nurses?
This younger generation of nurses included women who started using oral contraceptives during adolescence and were thus maximally exposed during their early reproductive life. Several case-control studies suggesting such exposures might be associated with substantial increases in breast cancer risk provided a particularly strong justification for investment in this large cohort. Researchers also planned to collect detailed information on the types of oral contraceptives used, which was not obtained in the Nurses’ Health Study.

In addition, NHS II obtained information on physical activity and diet in adolescence and early adult life.

The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older. Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. Measurements included traditional risk factors such as blood pressure and lipids as well as measures of subclinical disease, including echocardiography of the heart, carotid ultrasound, and cranial magnetic-resonance imaging (MRI). At six month intervals between clinic visits, and once clinic visits ended, participants were contacted by phone to ascertain hospitalizations and health status.

Information on dementia comes from two Ancillary Studies. The CHS Cognition Study (Dr. Lewis Kuller, PI) included 3608 participants who had an MRI in 1992-94 and who were followed for dementia through 1999. A follow-up study was done at the Pittsburgh field center that included 532 participants followed through 2013 (Dr. Oscar Lopez,PI).

The West of Scotland Twenty-07 Study: ‘Health in the community’ was set up in 1986 in order to investigate the reasons for differences in health by socio-economic circumstances, gender, the place where people live, age, ethnic group and family type.

The basic design of the Study involved recruiting three cohorts (groups) of volunteers, each group born twenty years apart. Members of the oldest cohort were born around 1932, those in the middle cohort were born in 1952, and those in the youngest cohort were born in 1972. A total of 4,510 people agreed to take part, and have been followed for 20 years. The final wave of data collection was completed in 2008. This means that when the Study began (1987/8) participants were 15, 35 or 55 years old, and by the end of the Study (2007/8), participants were 35, 55 and 75 years old.
The data collected are extensive and include self-reported mental and physical health (including chronic conditions, medications, disabilities); physical measures; biomarkers; cognition; life circumstances (including employment, housing, family); health behaviours; beliefs, attitudes and values. The cohort is being followed up for mortality using linkage to national records. Any data on neurodegenerative disease are from self-reported health and / or death certificates.
A full description of the cohort profile is available in the following publication: Cohort Profile: West of Scotland 20-07 study: health in the community. International Journal of Epidemiology 2009;38:1215-23

The Concord Health and Ageing in Men Project (CHAMP) is one of the world’s largest and most comprehensive study of the health of older men ever conducted anywhere in the world. CHAMP involves 1705 men aged 70 years and older recruited from the community living near Concord Hospital in Sydney’s inner west. Subjects were recruited during 2005 and 2006 and subjects were re-assessed after two, five and nine years. A 14 year follow-up assessment (wave 5) is planned for 2019. Clinical dementia assessment was done at baseline but not in waves 2, 3, and 4. Clinical dementia assessment will be included in wave 5.

The study is particularly concerned with cognitive impairment and dementia; falls, fractures and osteoporosis; and urinary problems.

The VLS is a long-term, large-scale, and multi-faceted longitudinal investigation of human aging. Incorporating biomedical approaches, leading-edge technologies, and epidemiological perspectives, the VLS evaluates and tracks actual cognitive, health, functional and lifestyle trajectories leading to outcomes that can be classified as normal, resilient, exceptional, impaired, or dementia. Our studies examine these differential brain and cognitive changes as a function of interactions among multiple “biomarkers” of both risk and protection. Among these dynamically interacting biomarkers are those representing selected aspects of biological, health, genetic, metabolic, vascular, lifestyle, physical fitness, cognitive activity, sex/gender, and demographic domains

Korea became an ageing society in 2000, as the proportion of those 65 or older reached 7% of the population. Thereafter, the country is expected to undergo a rapid ageing process. Korea was belated compared to other advanced countries in reaching the ageing society status, but it is expected to become a super-aged society around the same time as others.

Lacking in basic data on ageing, Korea is in need of a structured set of statistical data. – Institutional reform and policy-making in preparation against the aged society require systematic build-up of data that can track individuals’ labor participation, income and asset status, spending patterns, retirement decisions, impact of social welfare, health, and intra-family transfer of income, among others.

The purpose of KLoSA is to create the basic data needed to devise and implement effective social, economic policies to address the trends that emerge in the process of population ageing.

The data will help identify and observe different dimensions of an aged society, build datasets that enable studies in different fields, and generate data comparable with similar panel studies in other countries (eg. U.S., Europe) that can provide the basis for policy-making and academic studies.