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Cohort Acronym
ADC

Cohort type
Neurodegenerative disease-specific cohort

Disease
Alzheimer's disease, Dementia (unclassified), Frontotemporal dementia, Lewy body disease, Mild cognitive impairment (MCI), Other NDs not listed, Prion disease, Subjective memory complaints (SMC) or subjective cognitive decline (SCD), Vascular dementia

Participant type
Condition diagnosed

Profile
Recruitment Period 2004 - present 
Sample size at start or planned sample size if still recruiting 0  
Estimated Current Sample Size 5,000 to 9,999 
Age at Recruitment >30   
Gender Male and Female 
Abstract

The ADC was setup in 2004 by including all patients who come to the Alzheimer Center for diagnostic work up and who consent to give all data, collected as part of the routine diagnostic work up, for research. The aim is and was to facilitate research into new and existing biomarkers in the broadest sense, to establish diagnostic, prognostic and theragnostic values and further insight into the pathogenesis of neurodegenerative dementias. The data are collected on a weekly basis and consist of baseline data and annual follow up data. Since it is conception it has grown into one of the largest clinical databases in the dementia field. More info on setup, characteristics and data collection can be found in van der Flier WM, Pijnenburg YA, Prins N, Lemstra AW, Bouwman FH, Teunissen CE, van Berckel BN, Stam CJ, Barkhof F, Visser PJ, van Egmond E, Scheltens P.

Optimizing patient care and research: the Amsterdam Dementia Cohort. J Alzheimers Dis. 2014;41(1):313-27. doi: 10.3233/JAD-132306. PubMed PMID: 24614907.

Last Update 21/09/2017

 
Country Netherlands 
Contact details
Institution name VU University Medical Center 
Principal Investiator (PI) Professor Philip Scheltens 
Contact email PI Email: p.scheltens@vumc.nl 
Contact phone number 31204440816 
Address Alzheimer Center,
Department of Neurology,
VU University Medical Center,
Neuroscience Campus,
Amsterdam,
The Netherlands 
Funders (Core support) Innovatie Fonds Ziektekostenverzekeraars, Stichting Diorapthe and Stichting VUmc fonds 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision
Biological samples: Blood, Cerebral spinal fluid (CSF), CSF biomarker data available, Urine
Genotyping: Gene screening
Brain imaging: Electroencephalogram (EEG), Magnetic resonance imaging (MRI), Magnetoencephalography (MEG), Positron emission tomography (PET) - amyloid, Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking: Consent for brain donation
Lifestyle: Alcohol
Socio-economic: Education, Marital status
Health service utilisation: Formal health and social care service utilisation including private care
 
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