General population-based cohort
Based at the University of Bristol, the Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s, is a world-leading birth cohort study. Between April 1991 and December 1992 more than 14,000 pregnant women were recruited into the study and these women (some of whom had two pregnancies or multiple births during the recruitment period), the children arising from the pregnancy, and their partners have been followed up over two decades.
The cohort has been followed intensively with annual questionnaires for the mothers, fathers and the children from age 5. A 10% sample of children were seen 10 times between 4 and 61 months for clinic assessment. Annual clinic assessment of the whole cohort was conducted from the age of 7 to 13 and 15 to 17. Assessment at age 24/25 is currently planned.
Record linkage has been completed for Education, Hospital Episode Statistics, Clinical Practice Research Datalink and Death notification and cancer cases.
1 million biological samples are held including maternal blood and urine, umbilical cord blood, placentas, paternal blood and saliva and childrens blood, saliva and urine.
The study has been extended to include grandparents, siblings, and children of the children and recruitment is underway.
ALSPAC is part of CLOSER (Cohort & Longitudinal Studies Enhancement Resources) which aims to maximise the use, value and impact of the UK’s longitudinal studies.
Last update: 12/01/2017