General population-based cohort
Alzheimer's disease, Dementia (unclassified), Frontotemporal dementia, Lewy body disease, Mild cognitive impairment (MCI), Motor neurone disease, Other NDs not listed, Parkinson's disease, Prion disease, Spinal muscular atrophy (SMA), Spinocerebellar ataxia (SCA), Vascular dementia
The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of risk factors for cardiovascular disease in adults 65 years or older. Starting in 1989, and continuing through 1999, participants underwent annual extensive clinical examinations. Measurements included traditional risk factors such as blood pressure and lipids as well as measures of subclinical disease, including echocardiography of the heart, carotid ultrasound, and cranial magnetic-resonance imaging (MRI). At six month intervals between clinic visits, and once clinic visits ended, participants were contacted by phone to ascertain hospitalizations and health status.
Information on dementia comes from two Ancillary Studies. The CHS Cognition Study (Dr. Lewis Kuller, PI) included 3608 participants who had an MRI in 1992-94 and who were followed for dementia through 1999. A follow-up study was done at the Pittsburgh field center that included 532 participants followed through 2013 (Dr. Oscar Lopez,PI).
Collaborative Health Studies Coordinating Center
Building 29, Suite 210
University of Washington, Box 354922
6200 NE 74th Street
Seattle, WA 98115