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Cohort Acronym
ESPRIT

Cohort type
General population-based cohort

Disease
Alzheimer's disease, Dementia (unclassified), Mild cognitive impairment (MCI), Parkinson's disease, Subjective memory complaints (SMC) or subjective cognitive decline (SCD), Vascular dementia

Participant type
No diagnosis

Profile
Recruitment Period 1999-2001 
Sample size at start or planned sample size if still recruiting 1863  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment 65 and over   
Gender Male and Female 
Abstract

For the Esprit study, 1863 non-institutionalized persons aged 65 years and over were randomly recruited in 1999 from the Montpellier district electoral rolls, and re-examined 6-times at 2-3 yearly intervals. Objectives:

1) To determine current and lifetime prevalence as well as incidence of psychiatric disorder in the elderly;
2) to determine the risk factors for these disorders, their relative weight and interactions;
3) to study clinical heterogeneity;
4) to estimate the probability of transition towards a subsyndromic state or a given pathology;
5) to elaborate predictive etiological models.

 
Country France 
Contact details
Institution name Novartis, Agence Nationale de la Recherche, Regional government of Languedoc Roussillon, Inserm 
Principal Investiator (PI) Marie-Laure Ancelin and Karen Ritchie 
Contact email PI email: marie-laure.ancelin@inserm.fr; PI email: karen.ritchie@inserm.fr 
Contact phone number Tel: +33 4 99 61 45 62 
Address Inserm U1061, Montpellier, France 
Funders (Core support) Novartis, Agence Nationale de la Recherche, Regional government of Languedoc Roussillon, Inserm 

Variables Collected

Brain related measures: N/A
Funtional rating: Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Reproductive, Respiratory
Biological samples: Blood, Other, Saliva
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI), Magnetoencephalography (MEG)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Marital status, Occupation and employment
Health service utilisation: Formal health and social care service utilisation including private care
 
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