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Cohort Acronym
PRoBaND

Cohort type
Neurodegenerative disease-specific cohort

Disease
Parkinson's disease

Participant type
At-risk diagnosis, Condition diagnosed, No diagnosis

Profile
Recruitment Period 2012-2017 
Sample size at start or planned sample size if still recruiting 2,614  
Estimated Current Sample Size 2,614 
Age at Recruitment    
Gender Male and Female 
Abstract

Tracking Parkinson’s, or the PRoBaND study, is a UK-based study of Parkinson’s disease funded entirely by Parkinson’s UK.

There is a wide variation of symptoms and features of Parkinson’s driven by both genetic and external factors.  Our study aims to define and explain these variations by analysing the clinical expression of Parkinson’s in relation to genotypic variation. Tracking Parkinson’s is a multi-centre prospective longitudinal study, informed by epidemiological and biomarker data.

Participants were recruited into three categories:

  • Recent onset patients (diagnosed within the last three years) are followed up at 6-month intervals for four years, then every 18-months for a further three years.
  • Early onset (patients diagnosed before the age of 50) were followed up at one year.
  • Relatives (siblings) of the participants are followed up after three years.

Since 2012, we have been running at 70 sites across the UK.  Recruitment closed in November 2017 and our cohort consists of 2,270 people with Parkinson’s and 344 of their siblings.

NHS Greater Glasgow & Clyde is the study Sponsor and the coordinating study centre is based at the Institute of Neuroscience & Psychology at the University of Glasgow in Scotland.

 
Country United Kingdom 
Contact details
Institution name University of Glasgow 
Principal Investiator (PI) Donald Grosset 
Contact phone number Tel: +44 0141 330 2058 
Address Tracking Parkinson's
Institute of Neuroscience & Psychology
University of Glasgow
58 Hillhead Street, Room 702
Glasgow
G12 8QB
United Kingdom 
Funders (Core support) Parkinson's Disease UK 

Variables Collected

Brain related measures: N/A
Funtional rating: Caregiver, Individual physiological
Anthropometric: Blood pressure, Height, Weight
Physical: N/A
Biological samples: Blood
Genotyping: Gene screening
Brain imaging: N/A
Brain banking: N/A
Lifestyle: Dietary habits, Physical activity
Socio-economic: Ethnic group, Family circumstances, Martial status
Health service utilisation: Formal health and social care service utilisation including private care
 
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