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Cohort Acronym
SABRE
Cohort typeGeneral population-based cohort
Disease
Participant type
No diagnosis
Profile
Recruitment Period
1988
Sample size at start or planned sample size if still recruiting
4859
Estimated Current Sample Size
0 to 4,999
Age at Recruitment
40-69
Gender
Male and Female
Abstract
The Southall And Brent Revisited Study (SABRE) is the largest tri-ethnic population-based cohort in the UK, involving nearly 5000 European, Indian Asian and African Caribbean men and women. It investigates the causes of diabetes and disorders of the heart and circulation and examines underlying reasons for ethnic differences in risk of these disorders.
The participants were aged 40-69 when first studied between 1989 and 1991. In 2008-2011 a comprehensive combined morbidity and mortality follow up was carried out, together with non-invasive clinical measurements in order to quantify sub-clinical disease. SABRE visit 2 tested hypotheses generated from the Southall and Brent baseline studies and ongoing mortality follow-up.
SABRE Visit 3 (25 year follow-up visit) started in July 2014 and is collecting data on index participants and new participants, including partners of index participants. The focus of this visit is on cardiac, cognitive and physical function in older age, in association with mid-life risk factors. Ethnic and gender differences in function will also be examined.
Last update – 10/04/2017
Country
United Kingdom
Contact details
Institution name
University College, London
Principal Investiator (PI)
Professor Nish Chaturvedi
Contact phone number
02076 799471
Address
UCL Institute of Cardiovascular Science,
Gower Street,
London,
WC1E 6BT
Funders (Core support)
Wellcome Trust
British Heart Foundation
Variables Collected
Brain related measures: Cognitive function, Mental health, Neurological
Funtional rating: Caregiver, Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Musculoskeletal, Respiratory
Biological samples: Blood, Saliva, Urine
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Informal support, Marital status, Occupation and employment, Unpaid care
Health service utilisation: Formal health and social care service utilisation including private care
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