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Cohort Acronym
Alfa Study

Cohort type
Neurodegenerative disease-specific cohort

Disease
Alzheimer's disease, Mild cognitive impairment (MCI), Subjective memory complaints (SMC) or subjective cognitive decline (SCD)

Participant type
At-risk diagnosis

Profile
Recruitment Period Apr 2013-Nov 2014 
Sample size at start or planned sample size if still recruiting 2743  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment 45-75   
Gender Male and Female 
Abstract

The aim of the Alfa Study is to focus on the processes taking place before the initiation of Alzheimer’s symptoms in order to design interventions to prevent or delay the onset of dementia. Inclusion criteria were being cognitively normal Spanish and/or Catalan-speaking persons aged between 45 and 74 years that agreed with the study procedures and tests: clinical interview and questionnaires associated to risk factors, cognitive tests, a blood sample extraction for DNA analysis, and MRI.

A subset (n=450) of the ALFA parent cohort participants are currently being recruited / undergoing a nested longitudinal long-term study, named the ALFA+ study, in which a more detailed phenotyping will be performed. On top of a similar characterization as in the ALFA parent cohort, it will entail the acquisition of both wet (CSF, blood, and urine sample collection) and imaging (magnetic resonance imaging [MRI] and PET) biomarkers. Furthermore, ALFA parent cohort participants may also be invited to participate in other BBRC studies such the ALFAlife primary intervention study (n=400) or the full genetic and neuroimaging characterisation study referred to as ALFAgenetics (n=2000).

Last Update 21/09/2017

 
Country Spain 
Contact details
Institution name Barcelona?eta Brain Research Center 
Principal Investiator (PI) Dr. Jos' Luis Molinuevo 
Contact email PI Email: jlmolinuevo@fpmaragall.org  
Contact phone number Tel. +34 933160990 
Address Barcelona eta Brain Research Center
Wellington, 30
08005 Barcelona
Tel. +34 933160990 
Funders (Core support) Pasqual Maragall Foundation (FPM) 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: Caregiver, Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Musculoskeletal, Reproductive, Respiratory
Biological samples: Blood, Cerebral spinal fluid (CSF), CSF biomarker data available
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI), Positron emission tomography (PET) - amyloid, Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Marital status, Occupation and employment
Health service utilisation: Formal health and social care service utilisation including private care
 
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