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Cohort Acronym
(EADC) - (EAPP)

Cohort type
Neurodegenerative disease-specific cohort

Disease
Alzheimer's disease

Participant type
At-risk diagnosis

Profile
Recruitment Period 2009-2012 
Sample size at start or planned sample size if still recruiting 142  
Estimated Current Sample Size  
Age at Recruitment >18   
Gender Male and Female 
Abstract

The EADC-PET project (EAPP, The European Alzheimer’s Disease Consortium PET project) is a spontaneous multicentric study (ProtocolDraftSep2008; ProtocolDraftFeb2009) involving at the moment five Centres in four Countries (CENTRES), belonging to the EADC consortium. It was launched during the EADC meeting in Amsterdam, during fall 2007, by Flavio Nobili (Genoa) who is the Principal Investigator.

The project aims at sharing FDG-PET, MRI, neuropsychological, genetic, EEG and clinical information of patients with amnestic Mild Cognitive Impairment (aMCI) and matched healthy controls. Information is uploaded in a safe FTP facility on the server of University of Genoa. Username and password have been provided to all participants. Use of data is regulated by a ‘Confidentiality Disclosure Agreement’ that can be downloaded from this web site (Confidential_Disclosure_Agreement). The Centres propose original studies by sending a formal proposal to all participants who can agree or disagree, or propose modifications/suggestions to the original proposal.

The objective is to follow-up aMCI patients with clinical and neuropsychological examinations to pick up conversion to Alzheimer’s dementia or to other forms of dementia. FDG-PET can be analyzed by means of several post-processing strategies to highlight glucose metabolic information and to identify the characteristics of what is today called ‘prodromal’ AD.

Last Update 21/09/2017

 
Country France, Germany, Italy, Netherlands 
Contact details
Institution name Multiple 
Principal Investiator (PI) Flavio Nobili 
Contact email PI Email: flaviomariano.nobili@hsanmartino.it  
Contact phone number +39 010 3537568 
Address Clinical Neurology, Dept of Neuroscience (DINOGMI), Univ of Genoa, Largo Daneo, 3
I-16132 Genoa, Italy 
Funders (Core support)  

Variables Collected

Brain related measures: Cognitive function, Mental health, Neurological
Funtional rating: Individual psychological
Anthropometric: N/A
Physical: N/A
Biological samples: Cerebral spinal fluid (CSF), CSF biomarker data available
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI), Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking: N/A
Lifestyle: N/A
Socio-economic: Education
Health service utilisation: N/A
 
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