General population-based cohort
Alzheimer's disease, Dementia (unclassified), Huntington's disease, Mild cognitive impairment (MCI), Parkinson's disease, Subjective memory complaints (SMC) or subjective cognitive decline (SCD)
Convenience sample of centenarians, their siblings, offspring, spouses and a control sample consisting of people born around same time as offspring but who do not have parents surviving beyond average life expectancy for their birth cohort. Age range 40-119 years, with ~2500 centenarians in the sample including 600 semi-supercentenarians (ages 105-109) and 200 supercentenarians (ages 110+ years).
We collect the below listed data at enrolment and then collect vital status, hospitalization, changes in meds and diagnoses, cognitive function (TICS) and physical function (IADS, ADL) over the phone, annually. Local subjects are asked to undergo annual detailed cognitive function testing in person with ultimately, brain donation. Blood sample collected at enrolment for DNA, RNA and plasma for biomarkers and storage.
Study is open to collaborations. Please contact Dr. Perls
Section of Geriatrics, Robinson 2400
Boston Medical Center
88 E. Newton Street, Robinson 2400
Boston, MA 02118
The William M. Wood Foundation
The Martin and Paulette Samowitz Family Foundation