General population-based cohort
Alzheimer's disease, Dementia (unclassified), Frontotemporal dementia, Huntington's disease, Lewy body disease, Mild cognitive impairment (MCI), Motor neurone disease, Other NDs not listed, Parkinson's disease, Prion disease, Spinal muscular atrophy (SMA), Spinocerebellar ataxia (SCA), Vascular dementia
The Uppsala Birth Cohort Multigeneration Study (UBCoS) started in 2005 when we were first able to combine existing data on a representative and well-defined cohort of 14,192 males and females born in Uppsala from 1915-1929 (the Uppsala Birth Cohort: UBCoS) with information on descendants of the original cohort members obtained from routine registers.
In 2007-2011, the study was further developed by additional data collection in school archives and records from Census 1930 and the period of follow-up was extended till end of year 2009.
The study is unique in investigating intergenerational effects as “forward in time” processes, starting at the beginning of the last century (i.e. well before any of the routine registers were in place). Intergenerational associations can be currently investigated in more than 140,000 study subjects from families spanning up to five generations, including the 14,192 original cohort members, their 22,559 children, 38,771 grandchildren and 25,471 great grandchildren born up to 2009.
Dept Public Health Sciences
Stockholms universitet / Karolinska Institutet
SE - 106 91 Stockholm