Call Results

Results of the 2019 JPND call for “Personalised Medicine”

The eighteen projects were recommended for funding by an independent, international Peer Review Panel based on scientific excellence with input from the JPND advisory board on patient and public involvement. Proposals are presented in alphabetical order according to their acronym.

 

ADAIR
From air pollution to brain pollution – novel biomarkers to unravel the link of air pollution and Alzheimer’s disease

Coordinator:
Katja Kanninen, University of Eastern Finland, Finland

Partners:
Tarja Malm, University of Eastern Finland, Finland
Thomas Sandström, University of Umeå, Sweden
Rosalba Giugno, University of Verona, Italy
Anna Oudin, University of Umeå, Sweden
Jan Topinka, The Czech Academy of Science, Czech Republic
Arfan Ikram, Erasmus University Medical Center, The Netherlands
 

bPRIDE
blood Proteins for early Discrimination of dEmentias

Coordinator: 
Charlotte Teunissen, VU Medical Center, The Netherlands

Partners:
Niklas Mattsson, Lund University, Sweden
Colin Masters, The University of Melbourne, Australia
Markus Otto, Ulm University, Germany
Alberto Lleó, Hospital de la Santa Creu i Sant Pau, Spain
Lucilla Parnetti, University of Perugia, Italy
Jakub Hort, Charles University, Czech Republic


DIPPA-FTD
Diagnostic and prognostic precision medicine for behavioral variant frontotemporal dementia

Coordinator: 
Yolande Pijnenburg, Amsterdam University Medical Center, The Netherlands

Partners: 
Janine Diehl-Schmid, Technical University of Munich, Germany
Daniela Galimberti, University of Milan, Italy
Simon Ducharme, McGill University, Canada
Glenda Halliday, University of Sydney, Australia
 

E-DADS
Early Detection of Alzheimer’s Disease Subtypes

Coordinator:
Daniel Alexander, University College London, United Kingdom

Partners:  
Wiesje van der Flier, Stichting VU Medical Center, The Netherlands
Alberto Redolfi, IRCCS Fatebenefratelli, Italy
Stanley Durrleman, INRIA Brain and Spine Institute, France
Samantha Burnham, Commonwealth Scientific and Industrial Research Organisation, Australia


EU-FINGERS
EURO-FINGERS multimodal precision prevention toolbox for dementia in Alzheimer’s disease

Coordinator:
Miia Kivipelto, Karolinska Institute, Sweden

Partners:
Tiia Ngandu, National Institute for Health and Welfare, Finland
Tobias Hartmann, Saarland University, Germany
Philip Scheltens, VU Medical Center, The Netherlands
José Luis Molinuevo, IIS Instituto Hospital del Mar de Investigaciones Mèdicas, Spain
Jean Goerges, Alzheimer Europe, Luxemburg


GBA-PaCTS
GBA – personalised medicine for Parkinson disease: clinical and therapeutic Stratification

Coordinator:  
Anthony Schapira, University College London, United Kingdom

Partners:
Fabio Blandini, IRCCS Mondino Foundation National Institute of Neurology, Italy
Paolo Ciana, University of Milan, Italy
Michela Deleidi, University of Tübingen, Germany
Donato Di Monte, German Center for Neurodegenerative Diseases (DZNE), Germany
Jose Lanciego, Instituto de Investigación Sanitaria de Navarra (IdiSNA), Spain


GENFI-prox
Defining measures of proximity to symptom onset in the GENetic Frontotemporal dementia Initiative

Coordinator:
Jonathan Rohrer, University College London, United Kingdom

Partners: 
John van Swieten, Erasmus Medical Center, The Netherlands
Caroline Graff, Karolinska Institute, Sweden
Markus Otto, University of Ulm, Germany
Matthis Synofzik, University of Tübingen, Germany
Barbara Borroni, University of Brescia, Italy


Gums&Brain
Alzheimer’s disease as a co-morbidity of chronic periodontitis with Porphyromonas gingivalis as a causative link between both diseases

Coordinator:
Jan Potempa, Jagiellonian University, Poland

Partners:  
Hans-Ulrich Demuth, Fraunhofer Institute for Cell Therapy and Immunology IZI, Germany
Jan Kovalinka, Czech Academy of Science IOCB, Czech Republic
Jan Enghild, Aarhus University, Denmark
Piotr Mydel, University of Bergen, Norway
 

MIDDLE
Music Interventions for Dementia and Depression in ELderly care (MIDDEL): International cluster-randomised trial

Coordinator: 
Christian Gold, Norwegian Research Centre AS, Norway

Partners:   
Sytse Zuidema, University Medical Centre Groningen, The Netherlands
Justine Schneider, University of Nottingham, United Kingdom
Günther Kreutz, University of Oldenburg, Germany
Burçin Uçaner Çifdalöz, Ankara Haci Bayram Veli University, Turkey


NMJ-on-a-Chip
Humanized high-throughput co-culture system for motor neuron diseases

Coordinator:  
Eran Perlson, Tel-Aviv University, Israel

Partners:  
Benoit Charlot, CNRS/ University of Montpellier, France
Florence Rage, CNRS, France
Markus Krüger, University of Cologne, Germany
Silvestro Conticello, Istituto per lo studio, la prevenzione e la rete oncologica (ISPRO), Italy
Pim Pijnappel, Erasmus University Rotterdam, The Netherlands
Jósef Dulak, Jagiellonian University, Poland


OligoFIT
Oligomer-Focused Screening and Individualized Therapeutics to target Neurodegenerative Disorders

Coordinator:
Martin Bachmann, University of Oxford, United Kingdom

Partners:  
Kaspars Tars, Biomedical Research and Study Center, Latvia
Tiago Outeiro, University Medical Center Göttingen, Germany
Poul Henning Jensen, University of Aarhus, Denmark
Goreti Sales, Polytechnic School of Porto, Portugal
Piotr Hanczyc, University of Warsaw, Poland


ORGTHERAPY
Multicellular organoids: modeling, mechanisms and therapy development for C9ORF72-associated neurodegeneration

Coordinator:
Mimoun Azzouz, University of Sheffield, United Kingdom

Partners:     
Elena Kozlova, University of Uppsala, Sweden
Nicola Hamilton, King’s College London, United Kingdom
Esra Cagavi, Istanbul Medipol University, Turkey
Tarja Malm, University Eastern Finland, Finland
Guilhem Velvé-Casquillas, Elvesys, France


PMG-AD
Personalised medicine approach for novel microglia-associated genetic variants in Alzheimer’s disease

Coordinator:
Mikko Hiltunen, University of Eastern Finland, Finland

Partners:
Jean Charles Lambert, Institut Pasteur de Lille, France
Christian Haass, Ludwig-Maximilians University Munich, Germany
Jari Koistinaho, University of Helsinki, Finland
Stefan Lichtenthaler, Technical University Munich, Germany


PMI-AD
Precision Medicine Interventions in Alzheimer’s Disease

Coordinator:   
Tormod Fladby, University of Oslo, Norway

Partners:
Pieter Visser, VU University Medical Center, The Netherlands
Bengt Winblad, Karolinska Institute, Sweden
Milica Kramberger, University Medical Center Ljubljana, Slovenia
Kaj Blennow, University of Gothenburg, Sweden
Mads Nielsen, University of Copenhagen, Denmark


PREADAPT
Identification of personalized inflammatory profiles of aging and senescence which are modified specifically by risk factors of dementia modulating the predementia speed of symptomatic progression.

Coordinator:
Alfredo Ramirez, University of Cologne, Germany

Partners: 
Agustín Ruiz, Fundació ACE. Institut Català de Neurociències Aplicades, Spain
Michael Heneka, University Bonn, Germany
Natalie Marchant, University College London, United Kingdom
Jean-Charles Lambert, Institute Pasteur de Lille, France
Ruth Frikke-Schmidt, RegionH Rigshospitalet, Denmark
Reinhard Schneider, University of Luxembourg, Luxembourg


SORLA-FIX
Identifying and treating SORL1-associated Alzheimer’s disease

Coordinator:
Henne Holstege, Stichting VU University Medical Center, The Netherlands

Partners:
Olav Andersen, Aarhus, University, Denmark
Dasa Bohaciakova, Masaryk University Brno, Czech Republic
Arne Möller, Max-Planck Institute of Biophysics, Germany


STRATALS
Stratification of presymptomatic amyotrophic lateral sclerosis: the development of novel imaging biomarkers

Coordinator: 
Pierre-François Pradat, Pitié-Salpêtrière University Hospital, France

Partners:
Isabelle Le Ber, Pitié-Salpêtrière University Hospital, France
Daniel Alexander, University College London, United Kingdom
Julien Doyon, McGill University Montreal, Canada
Peter Bede, Trinity College Dublin, Ireland


TRIAGE
TRanslating Individual Alzheimer GEnetic risk into disease phenotypes

Coordinator:
Bart De Strooper, Flemish Institute for Biotechnology (VIB), Belgium

Partners:
Valentina Escott-Price, Cardiff University, United Kingdom
Jeroen Pasterkamp, University Medical Center Utrecht, The Netherlands
Rik Vandenberghe, University Hospital Leuven, Belgium