Category Archives: Uncategorized @sk

The EU Joint Programme – Neurodegenerative Disease Research (JPND) initiative[1] has launched its updated global Research and Innovation Strategy (RIS), to provide a unified framework for the support of world class research into neurodegenerative diseases.

Neurodegenerative diseases are one of the world’s leading medical and societal challenges and there are now expected to be 50 million people worldwide suffering from Alzheimer’s disease and related disorders. Globally, these numbers show no signs of abating, and it is estimated that by 2050 in Europe alone, the total direct and informal care costs for Alzheimer’s and Parkinson’s disease will exceed €350 billion annually.[2]

JPND is the first and largest collaborative research initiative established to tackle the growing challenge posed by neurodegenerative diseases. JPND’s ultimate goal is to accelerate the discovery of a cure and to enable early diagnosis for early personalised treatments. In the meantime, it is essential to implement solutions that can alleviate, albeit partially, the plight of families and the economic burden brought about by the increasing prevalence of this disease in our ageing populations. Thus besides basic research, the scientific endeavour concerns also translational and clinical, and social care and health services researches.

Today’s release of the Research and Innovation Strategy (RIS) updates the common vision of 30 JPND member countries. It renews the strategy that was first published in 2012, to tackle the major societal challenge of neurodegenerative diseases.

JPND speaks to the following individuals about the RIS.

Dr Barbara Kerstiëns, Head of the unit responsible for Non-Communicable Diseases and the Challenge of Healthy Ageing in the European Commissions‘ Directorate-General for Research & Innovation says: The European Commission is keenly aware that Neurodegenerative Diseases is one of the leading medical and societal challenges of our time. It recognises that JPND has been instrumental in addressing these by aligning and coordinating national efforts among Member States and other countries, reducing fragmentation and duplication in research and overall increasing the effectiveness and impact of research in this field.

JPND’s ambitious new RIS invites multidisciplinary and cross-sectoral collaboration as well as engagement with patients, their families and carers. Its five scientific priorities cover the full spectrum of unmet needs – the knowledge gap, the prevention gap, the early diagnosis and disease management gap, as well as the growing socio-economic challenges of caring for and assisting people faced with those diseases. The strategy takes important factors relating to ND care into account, such as comorbidities, sex and gender differences, the role of ageing and the complex ethical issues. Moreover, the RIS recommendations are in line with the Commission’s priorities in fostering innovative partnerships, taking advantage of the latest advances in digital technologies, including artificial intelligence, promoting an Open Access approach and translating research findings into evidenced-based public health policies and, ultimately, better health and social care.”

Professor Philippe Amouyel, University of Lille (France) and Chair of the JPND Management Board says: The challenge is to tackle neurodegeneration, and in particular, Alzheimer’s disease through an unprecedented collaboration at the European level and beyond. The ultimate goal is to facilitate the cooperation of researchers, to reduce fragmentation, to prevent unnecessary doubling of efforts and to pool and organise resources on a voluntary basis for the benefit of the populations. Our RIS forms the basis for current and future JPND initiatives, as well as a fundamental reference point for the national and organisational strategic plans. It provides a global common framework for future investment that addresses how countries can effectively improve prevention, diagnosis, treatment and patient care.

JPND Scientific Advisory Board Chair, Professor Thomas Gasser says:Since the publication of our first RIS in 2012, there have been major advances, both scientific and technological, that have shaped the renewed RIS. Data science, including artificial intelligence-driven methods of data analyses, has transformed many research areas, and this is now reflected in the updated Strategy. Another important issue reflected in the renewed Strategy is the increasing awareness that the inclusion of factors like economic and cultural differences, gender issues and public and patient involvement must clearly play a more prominent role.”  Click here for JPND’s full interview with Prof Gasser.

Professor Mogens Hørder, JPND Management Board Member says: “Since the 2012 research strategy, there has been an increased alignment of goals and methodologies being built up among research institutions of JPND members. The renewed RIS sees the participation of important players outside of Europe in JPND, which forms a valuable basis for the role of JPND in the global investment in neurodegenerative disease research.

For JPND Executive Board member Dr Jacqueline Hoogendam, “the value of collaborative research should not be underestimated.” She says: “With the common vision adopted by the 30 JPND member countries, JPND enables neurodegenerative disease research in the most pressing areas at a global level, with efficient use of limited resources. In bringing together researchers from different countries whose collaborations extend beyond their joint research activities, JPND contributes to the development of the global community of neurodegenerative disease researchers.

JPND is committed to aligning and building upon national programmes to increase impact and effectiveness of research and to identify common goals that would benefit from joint action.

JPND has identified a number of thematic scientific priorities for future research:

  • The origins and progression of neurodegenerative diseases
  • Disease mechanisms and models
  • Diagnosis, prognosis and disease definitions
  • Developing therapies, preventive strategies and interventions
  • Health and social care

JPND is working to implement the above goals through:

  • Building supportive infrastructure and platforms via harmonisation of data and materials and promotion of an open access approach to the sharing of data and resources
  • Partnering with industry and healthcare providers and promoting innovation within a multi-partner international funding framework
  • Developing greater interaction with regulators to integrate patient needs
  • Linking worldwide research efforts in neurodegenerative disease research
  • Utilising resources and infrastructure outside of Europe and better connecting global patient public involvement (PPI)
  • Building capacity through strengthening certain neurodegenerative disease research areas and establishing networks across and between disciplines and researchers
  • Developing an evidence-led educational approach to embed a research culture across the full spectrum of health, social and palliative care
  • Strengthening the connection to policy makers
  • Ensuring effective communication of the research agenda and engaging with a wide range of sectors and stakeholders

 

JPND receives support from the European Commission.

 

To download a full copy of the Research and Innovation Strategy, click here.

To download an Executive Summary of the Research and Innovation Strategy, click here.

For more information about the 2019 Research and Innovation Strategy, click here.

For the full interview with JPND’s Scientific Advisory Board Chair Thomas Gasser about the Research and Innovation Strategy, click here.

 

[1] Joint Programming is a collaborative approach supported by the European Commission in which countries define a common vision and a strategic research agenda, in order to address major societal challenges which are beyond the scale of any national research programme. The Joint Programme on Neurodegenerative Disease Research (JPND) was established as the pilot for this new type of coordinated approach to research.
[2] Maresova  et al.,Alzheimer’s and Parkinson’s Diseases: Expected Economic Impact on Europe-A Call for a Uniform European Strategy, 2016, Journal of Alzheimer’s Disease, 54(3):1123-1133.

 

 

The EU Joint Programme – Neurodegenerative Disease Research (JPND) initiative has announced a joint transnational call for multinational research on personalised medicine for neurodegenerative diseases.

Neurodegenerative diseases are debilitating and still largely untreatable conditions. These diseases are characterised by a large variability in their origins, mechanisms and clinical expression, requiring treatments that will need to take into account all these specificities. Deciphering this variability is one of the biggest challenges in the treatment of neurodegenerative diseases and the way forward is Precision Medicine, supported by highly personalised approaches for the greatest benefit of the patients.

In this context, in partnership with the European Commission, JPND announced today a new call, inviting multinational research teams to submit proposals for ambitious, innovative, multinational and multidisciplinary collaborative research projects to change the trajectory of these debilitating diseases through the development of Precision Medicine approaches.

JPND has chosen to focus in the area of Precision Medicine, which relates to the targeting of specific elements responsible for pathology in a given individual at a particular point in time. It is an emerging approach for disease prevention, diagnosis and treatment that takes into account individual variability in genes, biological/molecular characteristics together with environmental and lifestyle factors.

According to Professor Philippe Amouyel, University of Lille (France) and Chair of the JPND Management Board:

Professor Philippe Amouyel, Chair of JPND

“During the last ten years, researchers have progressively uncovered the high complexity and wide diversity of neurodegenerative diseases. We need now to complete and use this massive amount of knowledge to develop targeted approaches to more efficiently fight the dramatic progression of these diseases.”

According to Professor Thomas Gasser, University of Tübingen (Germany) and Chair of the JPND Scientific Advisory Board:

Progresses in precision medicine will be a unique way to develop innovative approaches to prevent, slow down and cure neurodegenerative diseases. This call aims to harness the necessary expertise across Europe and globally, to address this research challenge.

Professor Amouyel added: “With this in mind, JPND participating countries in close collaboration with the European Commission have identified precision medicine as a major issue to tackle the global challenge of neurodegenerative diseases.”

Proposals submitted under this call, which is open to applicants in 24 countries, must focus on Precision Medicine in one or several of the following research areas:

  • Diagnosis (e.g. biomarkers, imaging data, omics approaches, big data analyses)
  • Prevention (e.g. biomarkers for studying novel treatments and interventions, co-morbidities, digital technologies, stratification within cohort studies and clinical trials)
  • Care (e.g. improvement of social and health care systems, molecular profiling, imaging, lifestyle data)

Proposals must also relate to any or several of the following neurodegenerative diseases: Alzheimer’s disease and other dementias, Parkinson’s disease and PD-related disorders, Prion diseases, Motor Neuron diseases, Hungtington’s disease, Spinocerebellar ataxia and Spinal muscular atrophy. JPND is committed to Patient and Public Involvement, and proposals are expected to engage patients, carers and the public.

Pre-proposals must be submitted no later than 15:00h C.E.T. on March 12, 2019.

For more information about the call, please click here.

 

The EU Joint Programme on Neurodegenerative Disease Research (JPND) was established to better coordinate research efforts across countries and disciplines to more rapidly find causes, develop cures and identify better ways to care for people with neurodegenerative disease. Today more than 40 million people worldwide are estimated to be living with Alzheimer’s disease and related disorders – the most common class of neurodegenerative disease – and this figure is expected to rise in the coming decades. The JPND Research and Innovation Strategy identified research priorities and provided a framework for future investment and is available for download here.

Final call information will be published on the JPND website (www.jpnd.eu).

Launched on 1 November 2018, the European Brain Council (EBC)-coordinated EU project The European Brain Research Area (EBRA), was designed to respond to the Horizon 2020 call SC1-HCO-10-2018, entitled ‚Coordinating European brain research and developing global initiatives‘.

Aimed at reducing the fragmentation and duplication of research efforts and at fostering synergies through enhanced coordination of brain research efforts at the EU and global level, the EBRA project was created as a catalysing platform for brain research stakeholders (researchers, clinicians, patients, governments, funders and public institutions) to streamline and better co-ordinate brain research across Europe while fostering global initiatives.

The highly diversified nature of European public research represents a considerable obstacle in the European Research Area, especially in the field of brain research, where the complexity of brain imposes a coordinated research effort to advance the understanding of brain and its disorders.

The EU and its Member States have made considerable investments in brain research,  leading to a significant increase of initiatives in this area, particularly under Horizon 2020. Although these initiatives have generated considerable amounts of knowledge and innovative approaches, more coordinated efforts to identify gaps and highlight priorities are needed, to combat the complexity of the challenge.

Over the next three years, the EBRA Consortium will work to align and better coordinate research strategies across European and global brain initiatives; facilitating the emergence of research projects in specific areas in active clusters, and providing support for effective collaboration. This includes enabling the sharing of data and access to research infrastructures; increasing the visibility of the brain research portfolio as a whole and promoting the uptake of EBRA results to key stakeholders.

The Consortium consists of the EBC membership, the Network of European funding for Neuroscience research (NEURON), Joint Programme – Neurodegenerative Disease Research (JPND) and the Human Brain Project (HBP).


This project has received funding from the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No 825348

The EU Joint Programme – Neurodegenerative Disease Research (JPND) will shortly launch a new cohesive action with the European Commission – a call for “Multinational research projects on Personalised Medicine for Neurodegenerative Diseases”. More than €30 million have already been earmarked by JPND member countries and the European Commission for this action.

Neurodegenerative diseases are debilitating and still largely untreatable conditions. They are characterised by a large variability in their origins, mechanisms and clinical expression. When searching for a medical solution, e.g. a treatment or an optimised approach for care, this large variability constitutes a major hurdle if not controlled. Indeed a treatment addressing one disease pathway may not be useful for all patients experiencing the relevant symptoms. Thus, one of the greatest challenges for treating neurodegenerative diseases is the deciphering of this variability.

JPND has chosen to focus in the area of Precision Medicine, which relates to the targeting of specific elements responsible for pathology in a given individual at a particular point in time. It is an emerging approach for disease prevention, diagnosis and treatment that takes into account individual variability in genes, biological/molecular characteristics together with environmental and lifestyle factors.

Thus, the upcoming call for multidisciplinary research proposals conducted by JPND and the European Commission will focus on Precision Medicine in the following research areas:

  • Diagnosis (e.g. biomarkers, imaging data, omics approaches, big data analyses)
  • Prevention (e.g. biomarkers for studying novel treatments and interventions, co-morbidities, digital technologies, stratification within cohort studies and clinical trials)
  • Care (e.g. improvement of social and health care systems, molecular profiling, imaging, lifestyle data)

The following neurodegenerative diseases are included in the call:

  • Alzheimer’s disease and other dementias
  • Parkinson’s disease and PD‐related disorders
  • Prion diseases
  • Motor neuron diseases
  • Huntington’s disease
  • Spinocerebellar ataxia (SCA)
  • Spinal muscular atrophy (SMA)

This will be a two-step call, expected to be launched in early January 2019, with a likely pre-proposal submission deadline in March 2019. Further details will be provided with the launch of the call.

Please note:

All information regarding future JPND call topics is subject to change.

Final call information will be published on the call page.

The EU Joint Programme on Neurodegenerative Disease Research (JPND) has awarded funding to ten multi-national research teams in order to increase understanding of the factors that contribute to the quality and delivery of health and social care for neurodegenerative diseases.

Current research suggests strong potential for improving quality of life for those living with neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, with novel health and social care concepts and innovations focusing on the preservation of dignity, independence and social inclusion. Nevertheless, the availability and quality of such services vary considerably across Europe and beyond.

JPND has selected ten teams with ambitious, innovative and multi-disciplinary collaborative projects that address health and social care at both the macro level of systems and infrastructures and the individual level of patients, carers and families.

“While waiting for new treatments to emerge from basic and translational research, we need to support projects that could deliver immediate impactful developments which health and social care research and innovation may be able to achieve. This includes new insights that point to the potential for improved patient empowerment, civic participation and quality of life,” said Professor Philippe Amouyel, Chair of JPND. Our hope is that this work will lead to the adoption of novel health promotion strategies that will reduce the impact of disease for patients as well as for their families and carers.”

The ten projects were recommended for funding by an independent, international Peer Review Panel based on scientific excellence with input from the JPND advisory board on patient and public involvement. Proposals are presented in alphabetical order according to their acronym.

Visit the call page here.

ADDITION
Alzheimer’s disease data-driven insights on individual outcomes of importance

Coordinator:
Linus Jönsson, Karolinska Institutet, Sweden

Partners:
Wiesje van der Flier, VU University Medical Center, The Netherlands
Carole Dufouil, INSERM, University of Bordeaux, France

 

COGNISANCE
CO-desiGning demeNtia dIagnoSis ANd post-diagnostic CarE

Coordinator:

Henry Brodaty, University of New South Wales, Australia

Partners:
Lee-Fay Low, University of Sydney, Australia
Isabelle Vedell, McGill University, Canada
Frans Verhey F, Maastricht University, The Netherlands
Greta Rait, University College London, United Kingdom
Louise Robinson, Newcastle University Institute for Ageing, United Kingdom
Joanna Rymaszewska, Wroclaw Medical University, Poland


DOMINO-HD

Multi-Domain Lifestyle Targets for Improving ProgNOsis in Huntington’s Disease

Coordinator:
Monica Busse, Centre for Trials Research, Cardiff University, United Kingdom

Partners:
Madeleine Lowery, Insight Centre for Data Analytics, University College Dublin, Ireland
Esther Cubo, Hospital Universitario of Burgos, Spain
Grzegorz Witkowski, Institute of Psychiatry and Neurology, Warsaw, Poland
Bernhard Landwehrmeyer, University of Ulm, Germany
Hans Jung, University of Zurich, Switzerland

FCDS Study
Scaling up the Family Carer Decision Support Intervention: A transnational effectiveness-implementation evaluation

Coordinator:
Kevin Brazil, Queen’s University Belfast, United Kingdom

Partners:
Sharon Kaasalainen, McMaster University, Canada
Jenny van der Steen, Leiden University Medical Centre, The Netherlands
Nicola Cornally, University College Cork, Republic of Ireland
Martin Loucka, Center for Palliative Care, Czech Republic

HEALTHE-RND
European eHealth care model for rare neurodegenerative diseases

Coordinator:
Jiri Klempir, Charles University in Prague, Czech Republic

Partners:

Jennifer Hoblyn, Bloomfield Hospital, Trinity College Dublin, Ireland
Ferdinando Squitieri, Huntington and Rare Diseases Unit, IRCCS Casa Sollievo della Sofferenza Hospital, Italy
Wilco Achterberg, Leiden University Medical Center, Topaz Huntington Center Overduin, The Netherlands
Niels Chavannes, Leiden University Medical Center, Department of Public Health and Primary Care, The Netherlands
Bernhard Landwehrmeyer, University of Ulm, Germany
Stephen P McKenna, Galen Research, Manchester, United Kingdom


HOMESIDE

A HOME-based Spousal caregiver-delivered music Intervention for people living with DEmentia: A Randomised Controlled Trial

Coordinator:

Felicity Baker, The University of Melbourne, Australia

Partners:
Karette Stensæth, Norwegian Academy of Music, Norway
Helen Odell-Miller, Anglia Ruskin University, United Kingdom
Thomas Wosch, University of Applied Sciences Würzburg-Schweinfurt, Germany
Anna Bukowska, University of Physical Education in Krakow, Poland


iCARE-PD

Integrated Parkinson Care Networks: addressing complex care in Parkinson disease in contemporary society

Coordinator:
Tiago Mestre, The Ottawa Hospital Research Institute / University of Ottawa, Canada

Partners:
Carsten Eggers, Philipps University of Marburg, Germany
Álvaro Sanchez-Ferro, Fundación Investigación HM Hospitales, Spain
Olivier Rascol, Toulouse University Hospital, France
Timothy Lynch, The Mater Misericordiae University Hospital, Ireland
Evžen Růžička, Charles University, Czech Republic


OPTIM-PARK

Optimization of community resources and systems of support to enhance the process of living with Parkinson’s Disease: a multisectoral intervention

Coordinator:
Maria Carmen Portillo, University of Southampton, United Kingdom

Partners:

Maria Victoria Navarta, University of Navarra, Spain
Lydia López Manzanares, Hospital Universitario de la Princesa, Spain
Christina Foss, University of Oslo, Norway
Anita Haahr, VIA University College, Denmark


SHAPE

Self-management and HeAlth Promotion in Early-stage dementia with e-learning for carers – A randomised controlled trial

Coordinator:
Ingelin Testad, Stavanger University Hospital, Norway

Partners:

Geir Selbæk, Norwegian National Advisory Unit on Ageing and Health, Norway
Linda Clare, University of Exeter, United Kingdom
Martin Knapp, London School of Economics & Political Science, United Kingdom
Kaarin Anstey, University of New South Wales, Australia


SHARED

Social Health And Reserve in the Dementia patient journey

Coordinator:
Arfan Ikram, Erasmus MC Rotterdam, The Netherlands

Partners:

René Melis, Radboud UMC, The Netherlands
Anna-Karin Welmer, Karolinska Institutet, Sweden
Henry Brodaty, University of New South Wales, Australia
Daniel Davis, University College London, United Kingdom
Karin Wolf-Ostermann, University of Bremen, Germany
Joanna Rymaszewska, Wroclaw Medical University, Poland

Did you know that there are 10 JPIs (Joint Programming Initiatives) addressing societal challenges, from climate change to neurodegenerative diseases, through coordinated research and innovation in Europe? Watch the video below, created in honour of the tenth anniversary of JPIs, to find out more about how they are tackling some of the biggest issues facing our society.

From today, funders and researchers can access a database containing survey information spanning three decades-worth of global neurodegenerative disease research funding.

The new, expanded online database is the result of a large-scale mapping exercise of neurodegenerative disease research investments and infrastructure across Europe, Australia and Canada – all member countries of the EU Joint Programme for Neurodegenerative Diseases (JPND). It follows a smaller-scale survey completed in 2011.

Providing a snapshot of public and not-for-profit investment in the area, the new data captured in 2016 covers research funding and resources recorded as active on 1 January 2016.

Together with the existing 2011 data, the investments span a 28-year period, from 2002 to 2030. Combined with projects from the first exercise, the database now indexes more than 3,100 projects and resources.

Analysis of the data, published in an accompanying report, reveals that annual neurodegenerative research spending has increased by 34% across JPND since 2011, from €370 million up to €494 million.

The aim of this expanded, interactive resource is to share funding information, promote new collaborations and inform strategy, ultimately supporting scientific progress in the neurodegenerative disease area.

The latest 2016 mapping exercise captures 2,672 projects, ranging from large multinational research programmes to small investments and fellowship awards. It covers seven new JPND members and data from partners in 27 different countries, including JPND transnational awards for the first time.

Visitors can use the database to explore what type of research has been funded and look at profiles of past and current investments by multiple funders or within specific countries. Research organisations may find it useful to draw on the information as a basis for coordinating funding strategies and preventing duplication.

To increase the global reach of the data, it will also be displayed in the International Alzheimer’s and Related Dementias Research Portfolio (IADRP) database. This follows a new partnership between JPND, the U.S. National Institute on Aging (NIA), part of the National Institutes of Health (NIH), and the Alzheimer’s Association (AA). Reciprocally, relevant research from the NIH will be accessible via the JPND database later this year.

About the EU Joint Programme on Neurodegenerative Disease Research (JPND)

JPND brings together 30 countries to accelerate discovery by aligning research priorities, approaches and programmes. This has resulted in the creation of the largest global collaboration in the field and represents an innovative approach to finding causes, developing cures and identifying appropriate ways to care for people living with neurodegenerative diseases. To learn more about JPND, visit www.jpnd.eu.

Two major research funding entities in the EU and US are joining forces for the first time to optimise and harmonise research into neurodegenerative diseases. The EU Joint Programme on Neurodegenerative Disease Research (JPND) and the U.S. National Institute on Aging (NIA), part of the National Institutes of Health (NIH) announced today the creation of a new cross-initiative action to link and support collaborations between researchers working in the field.

NIH and JPND ran separate calls for proposals in 2017 to investigate common mechanisms and pathways in neurodegenerative diseases. With this joint action, researchers supported under the JPND call are invited to team up with researchers supported under the NIH call, and vice versa, to propose joint activities such as common workshops, data exchanges and pilot experiments. These activities will add value to the science being undertaken in ongoing projects by accelerating knowledge transfer between research groups.

„Collaboration is the key to progressing our understanding of the biological underpinnings of neurodegenerative disease,“ said JPND Chair Professor Philippe Amouyel. „These awards will offer NIH and JPND researchers the opportunity to more systematically and efficiently connect and share knowledge, tools and data. They will enhance current investigations into the fundamental mechanisms of neurodegenerative diseases while also planting the seeds of future collaboration.“

“This is a crucial time of expanding global interest and support for neurodegenerative disease research,” said Dr. Eliezer Masliah, director of the NIA’s Division of Neuroscience. “In our connected age, breakthroughs in Alzheimer’s, vascular dementia, Lewy body disease, frontotemporal dementia and other neurological disorders require teamwork, and we look forward to strengthening the scientific connections between talented researchers across the EU and the US.”

Four research projects were supported under NIH’s call, “PAS17-028 Common Mechanisms and Interactions Among Neurodegenerative Diseases (R01)”. JPND’s call for “Multinational research projects for Pathway Analysis across Neurodegenerative Diseases” resulted in the support of ten research consortia, covering a range of diseases including Alzheimer’s and Parkinson’s disease.

About the EU Joint Programme on Neurodegenerative Disease Research (JPND): JPND brings together 30 countries to accelerate discovery by aligning research priorities, approaches and programmes. This has resulted in the creation of the largest global collaboration in the field and represents an innovative approach to finding causes, developing cures and identifying appropriate ways to care for people living with neurodegenerative diseases. To learn more about JPND, visit www.jpnd.eu.

About the National Institute on Aging: The NIA leads the federal government effort conducting and supporting research on aging and the health and well-being of older people. The NIA is designated as the lead NIH institute for information on Alzheimer’s disease. It provides information on age-related cognitive change and neurodegenerative disease, including participation in clinical studies, specifically on its Alzheimer’s website.

 

 

JPND’s database of experimental models for Parkinson’s disease has recently been updated with 29 additional new pages on in-vivo mammalian models.

The database,  which was first made available to the community in 2017, is a unique collection aimed at presenting and fostering scientific discussion around the experimental models currently available to study Parkinson’s disease.

The database is continuously updated to reflect developments from the scientific literature and is a major effort by JPND to help researchers in the field. Together with an exhaustive description of each model and the studies that have already been done, there is a section for comments. You are welcome to add your comments to any of the models you have had experience with or to present alternative models.

We hope that you will join this growing community of scientists. To consult the database and add your contributions, please visit: https://www.neurodegenerationresearch.eu/models-for-parkinsons-disease/.

If you’d like any additional information, don’t hesitate to contact us directly at experimentalmodels@jpnd.eu.

 

 

The EU Joint Programme – Neurodegenerative Disease Research (JPND) has awarded funding to ten research projects to perform new network analyses in order to better understand the common underlying mechanisms involved in neurodegenerative diseases.

Previous research has already shown that similar molecular pathways are relevant in different neurodegenerative and other chronic diseases.  With this funding, JPND enables ten multidisciplinary consortia, made up of research teams in 14 countries, to further scrutinise these pathways. This combined analysis of diseases across traditional clinical boundaries, technologies and disciplines could lead to new scientific insights, a re-definition of clinical phenotypes and, ultimately, innovative approaches in the treatment of neurodegenerative diseases.

“The recent failures of a number of clinical trials for Alzheimer’s disease make clear that we are still far from fully understanding the biological underpinnings of neurodegenerative diseases,” said JPND Chair Professor Philippe Amouyel. “The ten world-class consortia selected for funding in this call bring together skills and knowledge from across different disciplines and countries. They are poised to open collaborative new investigations into the fundamental mechanisms that we see in multiple diseases but that we don’t yet understand. We hope that this research will result in new hypotheses that could lead to the next generation of therapeutic approaches.”

The ten projects were recommended for funding by an independent, international Peer Review Panel based on scientific excellence.

Click on the links below to learn more about each project supported under JPND’s 2017 Pathway Analysis call.

BRAIN-MEND: Biological Resource Analysis to Identify New Mechanisms and phenotypes in Neurodegenerative Diseases
Coordinator: 
Ammar Al-Chalabi, King’s College London, King’s Clinical Neuroscience Institute, London, UK
Partners:
Naomi Wray, University of Queensland, Brisbane, QLD, Australia
Gilbert Bensimon, Centre Hospitalier Universitaire de Nîmes, Nîmes, France
Orla Hardiman, Trinity College Dublin, Ireland
Adriano Chio, University of Turin, Italy
Jan Veldink, University Medical Center, Utrecht, Netherlands

EpiAD: Effect of early and adult-life stress on the brain epigenome: relevance for the occurrence of Alzheimer’s Disease and Diabetes-related dementia
Coordinator:
Johannes Gräff, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale Lausanne, Switzerland
Partners:
Froylan Calderon de Anda, Center for Molecular Neurobiology Hamburg, Hamburg, Germany
Ana Frank-Garcia, Department of Neurology, University Hospital La Paz, Madrid, Spain
Agnieszka Basta-Kaim, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

HEROES: The locus coeruleus: at the crossroad of dementia syndromes
Coordinator:
Mara Dierssen, Instituto Hospital del Mar de Investigaciones Mèdicas (IMIM), Barcelona, Spain
Partners:  
Yann Herault, Institut de Génétique Biologie Moléculaire et Cellulaire (IGBMC), Illkirch-Graffenstaden, France
Marie-Claude Potier, Institut du Cerveau et de la Moëlle Epinière (ICM), Paris, France
Peter Paul De Deyn, University Medical Center Groningen (UMCG), The Netherlands
André Strydom, University College London (UCL), United Kingdom

localMND: Common architecture of local proteome, transcriptome and translatome across Motor Neuron disorders
Coordinator:
Marina Chekulaeva, Berlin Institute for Medical Systems Biology, Berlin, Germany
Partners:
Igor Ulitsky, Weizmann Institute of Science, Rehovot, Israel
Vincenzo La Bella, Department of Experimental BioMedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy
Erik Storkebaum, Department of Molecular Neurobiology, Radboud University, Nijmegen, the Netherlands

LODE: Loss of neurotrophic factors in neurodegenerative Dementias: Back to the crossroads of proteins
Coordinator:
Roberta Ghidoni, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Partners: 
Giuseppe Di Fede, Foundation IRCCS Carlo Besta Neurological Institute, Milan, Italy
Katharina Landfester, Max Planck Institute for Polymer Research, Mainz, Germany
Maria Grazia Spillantini, University of Cambridge, Cambridge, UK

NEURONODE: Systems Analysis of Key Nodes in Neurodegenerative Diseases
Coordinator: 
Peter McCormick, Queen Mary University of London, United Kingdom
Partners:
Nicolas Locker, University of Surrey, United Kingdom
Carl Ernst, McGill University, Canada
Stephane Lefrancois, Institut National de la Recherche Scientifique, Laval, Canada
Andreas Schuppert, RWTH Aachen University, Germany
Andrew Ewing, University of Gothenburg, Sweden

Protest-70: Protecting protein homeostasis in synucleinopathies and tauopathies by modulating the Hsp70/co-chaperone network
Co-Coordinators:
Carmen Nußbaum-Krammer, Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), Heidelberg, Germany
Bernd Bukau, Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), Heidelberg, Germany
Partners:
Ronald Melki, Paris-Saclay Institute of Neuroscience, CNRS, France
Harm Kampinga, Faculty of Medical Sciences, University of Groningen, Netherlands
Christian Hansen, Faculty of Medicine, Lund University, Sweden

RNA-NEURO: Systems Analysis of novel small non-coding RNA in neuronal stress responses: towards novel biomarkers and therapeutics for neurodegenerative disorders
Coordinator:
Jochen Prehn, Royal College of Surgeons in Ireland, RCSI Centre for Systems Medicine, Dublin, Ireland
Partners:
Ruth Slack, University of Ottawa, Canada
Jørgen Kjems, Aarhus University, Denmark
Mark Helm, University of Mainz, Germany
Giovanni Nardo, IRCCS-Mario Negri Institute, Milan, Italy
Michael Adriaan van Es, University Medical Center, Utrecht, Netherlands

TransNeuro: Altered mRNA translation as a pathogenic mechanism across neurodegenerative diseases
Coordinator:
Erik Storkebaum, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands
Partners:
Nahum Sonenberg, McGill University, Montreal, Canada
Marie-Christine Chartier-Harlin, Inserm UMRS1172, Lille, France
Erin Schuman, Max Planck Institute for Brain Research, Frankfurt, Germany
Kobi Rosenblum, University of Haifa, Haifa, Israel
Giovanna Mallucci, University of Cambridge, Cambridge, UK

TransPathND: Intraneuronal transport-related pathways across neurodegenerative diseases
Coordinator:
Michel Simonneau, Laboratoire Aimé Cotton, ENS Paris-Saclay, Orsay, France
Partners: 
Ronald Melki, Paris-Saclay Institute of Neuroscience, CNRS, Gif-sur-Yvette, France
August B. Smit, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Netherlands
Nicolas Le Novere, Babraham Institute, Cambridge, United Kingdom