C. Franceschi, N. Pedersen, K. Mills, G. Giaccone
ADAGE: Alzheimer's Disease pathology within the ageing physiology.
Alzheimer's disease & other dementias
Everybody grows old. But while some people grow old in good health, others experience severe disease, such as Alzheimers disease. Recent research demonstrates that Alzheimers disease shares several features with the ageing process and suggests that the pathology is the consequence of something that goes wrong during physiological ageing. Researchers involved in ADAGE (Alzheimers Disease+AGEing) will use the most advanced biomolecular approaches to compare Alzheimers disease patients with people who have stayed healthy in old age, including nonagenarians and centenarians. In this way, resear- chers aim to identify early biomarkers of the disease that will provide new diagnostic, pro- gnostic and therapeutic targets. The ADAGE consortium includes researchers from four insti- tutes in three EU countries (Italy, the UK and Sweden), and will also collaborate with three additional teams in Italy and Switzerland.