Dr Alexandra Grubman
Anti-inflammatory copper complexes for treatment of Alzheimer's Disease
Alzheimer's disease & other dementias
neurodegeneration | metal metabolism | neuroinflammation | alzheimer disease | stem cells
Brain inflammation and disrupted metabolism of the biologically important metal, copper, play key roles in Alzheimers disease (AD) progression. Our team has developed new copper-based therapeutics, but limited knowledge of how they work impedes clinical trials. My recent findings indicate that these drugs potently prevent inflammation. My proposal seeks to understand how copper-complexes reduce damaging inflammatory responses in novel human cell models of AD.