Name of Resource

    ArcAbeta Mouse (University of Zurich +ETH)

    Name of Principal Investigator - Title

    Prof

    Name of Principal Investigator - First name

    Jan

    Name of Principal Investigator - Last name

    Klohs

    Address of institution -Institution

    Inst. for Biomedical Engineering, University of Zurich + ETH

    Address of institution - Street address

    Valdimir-Prelog-Weg 4

    Address of institution - City

    Zurich

    Address of institution - Postcode

    8093

    Country

    Switzerland

    Summary

    The arcAbeta mouse belongs to the family of amyloid precursor protein expressing mouse lines. It shows age-dependent amyloid pathology with a strong vascular phenotype. Cognitive deficits can be detected by behavioral tests of hippocampal-dependent memory formation.

    Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions? (1)

    Alzheimer's disease and other dementias

    Q1b. Does your resource hold

    Animals

    Q2a. Does the resource act as a centre for access and distribution to external groups (who are not the Principal Investigators (PI) for the resource)?

    Yes

    Q2b. If Yes, what procedures and rules apply for access?

    Apply to PI or co-ordinator at resource| Access through collaboration with PI only| International Access

    Q3a. Does your resource develop experimental models (animal/cell) for external groups?

    No

    Q3b. If YES and your resource is related to an ANIMAL model, what types of models are provided?

    Not applicable

    Q3c. If YES and your resource is related to a CELL model, what types of models are provided?

    Q4a. Is this activity supported as:

    Q4b. Do you deposit what you supply in any kind of central repository?

    Disease

    AD

    Species

    Rat

    Available to external user

    Yes

    Full phenotypic character

    Intracellular punctate deposits of amyloid. Amyloid plaque formation and cerebral amyloid angiopathy. Robust cognitive impairment starting at 5 months of age

    Please indicate the phenotypes

    List of genotypes or other subtypes

    express human APP with the combined Swedish and Arctic mutations

    Q5b. Cognitive function, No of models

    Q5b. Cognitive function, Available to external users

    Q5b. Cognitive function, Full phenotypic characterisation

    Q5b. Cognitive function, Nature of phenotype

    Q5b. Motor function, No of models

    Q5b. Motor function, Available to external users

    Q5b. Motor function, Full phenotypic characterisation

    Q5b. Motor function, Nature of phenotype

    Q5b. Physiological function, no of models

    Q5b. Physiological function, Available to external users

    Q5b. Physiological function, Full phenotypic characterisation

    Q5b. Physiological function, Nature of phenotype

    Q5b. Other function (please specify), no of models

    Please specify other function

    Q5b. Other function (please specify), Available to external users

    Q5b. Other function (please specify), Full phenotypic characterisation

    Q5b. Other function (please specify), Nature of phenotype

    Q6. Please indicate if your resource is already linked into European or international consortia or networks?

    Q7a. Is maintenance of this resource dependent on continued funding?

    No

    Q7b. If yes, when does the current funding period end?

    Q7c. What is the expected lifespan of the resource (in years)?

    Not determined

    Q7d. Are there other plans affecting future use that it may be useful to know?

Types: Experimental Models
Member States: Switzerland
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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