FELISMINA TEIXEIRA COELHO MOREIRA
Biomedical devices for easier and quicker screening procedures of the Alzheimer disease
Parkinson's disease & PD-related disorders
Alzheimer´s disease (AD) is a progressive and degenerative disease of the central nervous system. It is the main cause of memory loss and dementia in the elderly, affecting currently ~90,000 people in Portugal. Early detection and diagnosis of AD is a major goal, because early clinical intervention may slow-down the progression of the disease.
This plan proposes for this purpose new portable biosensors for multi-biomarker screening of AD in point-of-care. This is achieved by: (i) developing novel synthetic capture-probes for targeted AD biomarkers; (ii) including such probes in a nanostructured material displaying good electrical features and compatibility with electrical transducers; (iii) adapting each of the previous materials to a low-cost support (paper, cork or PET). As this work is running side-by-side with the Starting Grant/ERC-3Ps, attempts will be made to fuse the device with a solar-cell operation, aiming at its full autonomy. Multi-biomarker platforms are also tried out.