Name of resource

BIOTERIO – Centre for Neuroscience and Cell Biology, FMUC

Name of Principal Investigator
Title Dr/Dr
First name
Last name Pereira/Rego
Address of institution where award is held
Institution Center for Neuroscience and Cell Biology (CNC) – Univ Coimbra
Street Address R. Larga, 6
City Coimbra
Postcode 3004-517
Country
  • Portugal
  • Website

    http://www.cnbc.pt/

    Contact email
    Summary
    1a. The resource holds animal models relevant to the study of the following neurodegenerative diseases
  • Alzheimer’s disease and other dementias
  • Huntington’s disease
  • 1b. The resource holds:
  • Animals
  • 2a. The resource acts as a centre for access and distribution to external groups (who are not the PIs of the resource)
    2b. Procedures and rules for access
  • Apply to PI or co-ordinator at resource
  • Access through collaboration with PI only
  • Applicant needs to provide separate external ethics approval
  • Other requirements exist
  • National access
  • International access
  • Other requirements exist
  • 3a. Does the resource develop animal models for external groups

    1

    3b. Types of models provided
  • Not applicable
  • 4a This activity is supported as:
  • Not applicable
  • 4b. The supplied material deposited in a central repository

    1

    5a Disease models available
    Disease Species Available to external user (Y/N) Full phenotypic character (Y/N or partial) Phenotypes Genotypes or other subtypes
    AD N Y Cognitive deficits, senile plaques, neurofibrillary tangles, synaptic loss in cerebral cortex and hippocampus 3xTg-AD (human mutant APP, PS1, tau)- background C57BL x 129sv Mouse
    YAC mouse model of HD expressing full-length human mutant huntingtin with 128 glutamines (YAC128, lines HD55 and HD53) HD Mouse Y Y Hyperkinetic phenotype first manifested, followed by progressive motor deficits and age-dependent striatal neurodegeneration
    7a. Maintenance of the resource is dependent on continued funding

    2

    7b. End date of current funding period

    2013

    7c. Expected lifespan of the resource (in years)

    10

    7d. Other plans affecting future use

    In one year more space available for production of new mice models colonies.

    In three years probably a new facility.

    Types: Experimental Models
    Member States: Portugal
    Diseases: Alzheimer's disease & other dementias, Huntington's disease
    Years: 2011
    Database Categories: N/A
    Database Tags: N/A

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