Prof Ashley Bush
Brain metal neurochemistry: mechanism-driven drug discovery for neurodegeneration
Alzheimer's disease & other dementias
alzheimer disease | metal metabolism | biomarkers | iron | protein biochemistry
Alzheimers disease (AD) is a complex disease where certain proteins congeal in the brain and metals accumulate. This project investigates the function of the proteins in microscopically transporting the metals. It will also look for tests that predict the onset of AD by measuring iron and iron related proteins by using special brain imaging (MRI), and measurements in spinal fluid. Finally, it will test drug candidates that target the metals, in animal models of AD, and in early clinical trials.