Name of resource
BRAINS Unit, Lund University
Name of Principal Investigator
| Title | Professor |
| First name | Deniz |
| Last name | Kirik |
Address of institution where award is held
| Institution | Lund University |
| Street Address | BMC D11 |
| City | Lund |
| Postcode | 22184 |
Country
Sweden
Website
http://www.med.lu.se/expmed/brains
Contact email
Summary
We run a small vector production facility that makes high quality AAV vectors that we use to develop animal models of PD and HD.
1a. The resource holds animal models relevant to the study of the following neurodegenerative diseases
Parkinson’s disease Huntington’s disease
1b. The resource holds:
Animals Frozen embryos Genetic material (DNA, RNA, vectors etc)
2a. The resource acts as a centre for access and distribution to external groups (who are not the PIs of the resource)
2b. Procedures and rules for access
Access through collaboration with PI only
3a. Does the resource develop animal models for external groups
1
3b. Types of models provided
4a This activity is supported as:
Independent of collaboration
4b. The supplied material deposited in a central repository
1
5a Disease models available
| Disease | Species | Available to external user (Y/N) | Full phenotypic character (Y/N or partial) | Phenotypes | Genotypes or other subtypes |
| PD | rat, mouse, primate | partial | partial | DA cell loss | alpha-synuclein |
| HD | rat, mouse | partial | partial | metabolic dysfunction | huntingtin |
5b. Other models/phenotypes available through the resource relevant to neurodegenerative conditions
| No. of models | Available to external users | Full phenotypic characterisation available (Y/N or partial) | Nature of phenotype |
| 1 | partial | partial | behavior and pathology |
| 2 | partial | partial | behavior and pathology |
6. European or international consortia or networks to which the resource is linked
| Jackson Laboratories, USAInternational mouse knockout consortium |
| Neugene |
| MEFOPA |
| Neurasyn |
7a. Maintenance of the resource is dependent on continued funding
2
7b. End date of current funding period
2012-13
7c. Expected lifespan of the resource (in years)
2