University of Tampere
Centre of Excellence in Research on Mitochondria, Metabolism and Disease (FinMIT)
Academy of Finland
Neurodegenerative disease in general|Parkinson's disease & PD-related disorders
Dysfunction of mitochondria, our cells’ power supply, underlies a variety of diseases, including Parkinsons Disease, deafness and various types of muscle and brain disease. Its role in acquired traits such as obesity is also increasingly recognized. FinMIT aims to understand the detailed molecular defects that cause mitochondrial diseases, focusing especially on neurodegeneration and obesity. We combine leading international expertise and tools from basic biology and medicine, to determine how mitochondrial failure disturbs cell function and the systems of chemical communication between different organs of the body. We aim to develop novel means of diagnosis and treatment, based on 1/ nutritional modification, 2/ new drugs designed to restore metabolic balance and 3/ the introduction of a metabolic by-pass to reconfigure the cells bioenergy system. This will benefit adults and children suffering from these typically progressive, devastating and currently incurable diseases.