SMITH, CAROLYN B
National Institute of Mental Health
Cerebral Protein Synthesis as a Measure of Degenerative Changes in a Transgenic Rat Model of Alzheimers Disease
Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Basic Behavioral and Social Science... Behavioral and Social Science... Brain Disorders... Dementia... Mental Health... Neurodegenerative... Neurosciences
During the 2016 funding period, we carried out studies to measure rCPS with the autoradiographic L-1-C-14leucine method in cohorts of WT and TgF344-AD at six, 14, and 18 months of age. In these animals we also measured activity by means of open field behavior, memory by means of the T-maze, olfaction by means of the buried food task, and sleep behavior. In a separate cohort of animals studied longitudinally we measured rCPS with the L-1-C-11leucine PET method. We have completed the behavioral testing and we are in the process of analyzing the results of the rCPS experiments.