Principal Investigators


RENARD Pierre-Yves

Institution


COBRA Rouen

Contact information of lead PI


Country


France

Title of project or programme


Click strategies for multifunctional anti-Alzheimer agents

Source of funding information


ANR

Total sum awarded (Euro)


€ 408,000

Start date of award


01/11/2012

Total duration of award in years


4

Keywords


Research Abstract


Click strategies for multifunctional anti-Alzheimer agents
The aim of this project is to synthesize multi-target directed ligands (MTDLs) aimed at the treatment of Alzheimer disease (AD) through the assembly of high-affinity precursors via click chemistry.
Evaluation of new «click« reactions adaptable to kinetic TGS and exploitation of these reactions to produce molecules in order to develop a new treatment toward Alzheimer’s disease.
Alzheimer’s disease, which is the most common cause of senile dementia, is a major public health issue. In this context, the objective of this project is to evaluate new «click« reactions adaptable to kinetic target guided synthesis (TGS), and our ultimate goal is to exploit these reactions to produce molecules that will aid fighting Alzheimer’s disease.
Development of new click reactions and application of the discovery of new treatment towards Alzheimer’s disease
Alzheimer Disease is a multifaceted illness requiring the combination of synergetic treatment strategies. We have thus chosen to use new click reactions to prepare new multi-target directed ligands (MTDLs) that will act simultaneously on the different players in AD pathology and, thereby, will allow a more efficient treatment of AD

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