Title of the cohort

Cohort – Seniors Quid

Acronym for cohort

PAQUID

Name of Principal Investigator
Title Professor
First name
Last name DARTIGUES
Address of institution where award is held
Institution
Street Address
City Bordeaux
Postcode 33076
Country
  • France
Website

http://www.isped.u-bordeaux2.fr/

Contact email

jean-francois.dartigues@isped.u-bordeaux2.fr

Funding source

CNSA BEAUFOUR IPSEN, NOVARTIS PHARMA

1. The cohort includes, or expects to include, incidence of the following conditions
  • Alzheimer’s disease and other dementias
  • Parkinson’s disease
When studies on the above condition(s) are expected to become possible
  • Already possible
2a. Stated aim of the cohort

Studying brain and functional aging after 65 years, distinguish the normal and pathological conditions, and identify people at high risk of physical or mental deterioration in which preventive action could be possible

2b. Features distinguishing this cohort from other population cohorts

Representative cohort of the French population aged 65 and over

3a. i) Number of publications that involve use of cohort to date

151

3a. ii) Up to three examples of studies to date (PI, Institution, Title of Study)

Risk factor for dementia and Alzheimer’s disease (social support, reactivation of herpes viruses, leisure)
Natural history of Alzheimer’s disease
Risk factor for Parkinson’s disease

3b. Publication list/link to where data or publications are accessible (if available)

Alperovitch, A., P. Amouyel, et al. (2002). “[Epidemiological studies on aging in France: from the PAQUID study to the Three-City study].” C R Biol 325(6): 665-672.

Amieva, H., H. Jacqmin-Gadda, et al. (2005). “The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study.” Brain 128(Pt 5): 1093-1101.

Amieva, H., M. Le Goff, et al. (2008). “Prodromal Alzheimer’s disease: successive emergence of the clinical symptoms.” Ann Neurol 64(5): 492-498.

Amieva, H., I. Rouch-Leroyer, et al. (2000). “Deterioration of controlled processes in the preclinical phase of dementia: a confirmatory analysis.” Dement Geriatr Cogn Disord 11(1): 46-52.

Amieva, H., R. Stoykova, et al. (2010). “What aspects of social network are protective for dementia? Not the quantity but the quality of social interactions is protective up to 15 years later.” Psychosom Med 72(9): 905-911.

Andersen, K., L. J. Launer, et al. (1999). “Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. EURODEM Incidence Research Group.” Neurology 53(9): 1992-1997.

Antonucci, T. C., R. Fuhrer, et al. (1997). “Social relations and depressive symptomatology in a sample of community-dwelling French older adults.” Psychol Aging 12(1): 189-195.

Antonucci, T. C., J. E. Lansford, et al. (2001). “Widowhood and illness: a comparison of social network characteristics in France, Germany, Japan, and the United States.” Psychol Aging 16(4): 655-665.

Aublet-Cuvelier, B., P. Barberger-Gateau, et al. (1991). “[Adequacy of homemaker services in Gironde according to the PAQUID program].” Rev Epidemiol Sante Publique 39(2): 121-128.

Auriacombe, S., N. Lechevallier, et al. (2006). “A longitudinal study of quantitative and qualitative features of category verbal fluency in incident Alzheimer’s disease subjects: results from the PAQUID study.” Dement Geriatr Cogn Disord 21(4): 260-266.

Baldi, I., P. Lebailly, et al. (2003). “Neurodegenerative diseases and exposure to pesticides in the elderly.” Am J Epidemiol 157(5): 409-414.

Barberger-Gateau, P., A. Alioum, et al. (2004). “The contribution of dementia to the disablement process and modifying factors.” Dement Geriatr Cogn Disord 18(3-4): 330-337.

Barberger-Gateau, P., A. Chaslerie, et al. (1992). “Health measures correlates in a French elderly community population: the PAQUID study.” J Gerontol 47(2): S88-95.

Barberger-Gateau, P., D. Commenges, et al. (1992). “Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers.” J Am Geriatr Soc 40(11): 1129-1134.

Barberger-Gateau, P., J. F. Dartigues, et al. (1993). “Four Instrumental Activities of Daily Living Score as a predictor of one-year incident dementia.” Age Ageing 22(6): 457-463.

Barberger-Gateau, P., C. Fabrigoule, et al. (2002). “The disablement process: a conceptual framework for dementia-associated disability.” Dement Geriatr Cogn Disord 13(2): 60-66.

Barberger-Gateau, P., C. Fabrigoule, et al. (1999). “Functional impairment in instrumental activities of daily living: an early clinical sign of dementia?” J Am Geriatr Soc 47(4): 456-462.

Barberger-Gateau, P., C. Fabrigoule, et al. (1999). “Neuropsychological correlates of self-reported performance in instrumental activities of daily living and prediction of dementia.” J Gerontol B Psychol Sci Soc Sci 54(5): P293-303.

Barberger-Gateau, P., L. Letenneur, et al. (2002). “Fish, meat, and risk of dementia: cohort study.” BMJ 325(7370): 932-933.

Barberger-Gateau, P., C. Nejjari, et al. (1995). “Assessment of disability and handicap associated with dyspnoea in elderly subjects.” Disabil Rehabil 17(2): 83-89.

Barberger-Gateau, P., C. Rainville, et al. (2000). “A hierarchical model of domains of disablement in the elderly: a longitudinal approach.” Disabil Rehabil 22(7): 308-317.

Bergua, V., C. Fabrigoule, et al. (2006). “Preferences for routines in older people: associations with cognitive and psychological vulnerability.” Int J Geriatr Psychiatry 21(10): 990-998.

Berr, C., J. F. Dartigues, et al. (1994). “Cognitive performance and three-year mortality in the PAQUID elderly study.” Rev Epidemiol Sante Publique 42(4): 277-284.

Berr, C., S. Lafont, et al. (1996). “Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study.” Proc Natl Acad Sci U S A 93(23): 13410-13415.

Berr, C., A. Nicole, et al. (1993). “Selenium and oxygen-metabolizing enzymes in elderly community residents: a pilot epidemiological study.” J Am Geriatr Soc 41(2): 143-148.

Berraho, M., C. Nejjari, et al. (2010). “Body mass index, disability, and 13-year mortality in older French adults.” J Aging Health 22(1): 68-83.

Bourdel-Marchasson, I., B. Dubroca, et al. (1998). “Five-year mortality in elderly French subjects from the PAQUID epidemiologival survey: the burden of diabetes.” Diabet Med 15(10): 830-835.

Bourdel-Marchasson, I., B. Dubroca, et al. (2000). “Incidence and predictors of drug-treated diabetes in elderly French subjects. The PAQUID Epidemiological Survey.” Diabet Med 17(9): 675-681.

Bourdel-Marchasson, I., B. Dubroca, et al. (1997). “Prevalence of diabetes and effect on quality of life in older French living in the community: the PAQUID Epidemiological Survey.” J Am Geriatr Soc 45(3): 295-301.

Cadot, S., C. Canet, et al. (1991). “[First gerodontic inquiries: PAQUIDENT after one year].” Chir Dent Fr 61(555): 5-10.

Carcaillon, L., K. Peres, et al. (2007). “Fast cognitive decline at the time of dementia diagnosis: a major prognostic factor for survival in the community.” Dement Geriatr Cogn Disord 23(6): 439-445.

Commenges, D., M. Gagnon, et al. (1992). “Improving screening for dementia in the elderly using, Mini-Mental State Examination subscores, Benton’s Visual Retention Test, and Isaacs’ Set Test.” Epidemiology 3(2): 185-188.

Commenges, D., M. Gagnon, et al. (1992). “Statistical description of the Mini-Mental State Examination for French elderly community residents. Paquid Study Group.” J Nerv Ment Dis 180(1): 28-32.

Commenges, D., P. Joly, et al. (2004). “Incidence and mortality of Alzheimer’s disease or dementia using an illness-death model.” Stat Med 23(2): 199-210.

Commenges, D., L. Letenneur, et al. (1994). “Test of homogeneity of binary data with explanatory variables.” Biometrics 50(3): 613-620.

Commenges, D., L. Letenneur, et al. (1998). “Modelling age-specific risk: application to dementia.” Stat Med 17(17): 1973-1988.

Commenges, D., V. Scotet, et al. (2000). “Intake of flavonoids and risk of dementia.” Eur J Epidemiol 16(4): 357-363.
Dantan, E., P. Joly, et al. (2011). “Joint model with latent state for longitudinal and multistate data.” Biostatistics.
Dantzer, C., J. F. Tessier, et al. (2001). “Mortality of elderly subjects with self-reported asthma in a French cohort, 1991-1996.” Eur J Epidemiol 17(1): 57-63.
Dartigues, J. F., L. Carcaillon, et al. (2007). “Vasodilators and nootropics as predictors of dementia and mortality in the PAQUID cohort.” J Am Geriatr Soc 55(3): 395-399.
Dartigues, J. F., D. Commenges, et al. (1997). “Cognitive predictors of dementia in elderly community residents.” Neuroepidemiology 16(1): 29-39.
Dartigues, J. F., M. Gagnon, et al. (1992). “The Paquid epidemiological program on brain ageing.” Neuroepidemiology 11 Suppl 1: 14-18.

Dartigues, J. F., M. Gagnon, et al. (1992). “Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid).” Am J Epidemiol 135(9): 981-988.

Dartigues, J. F., M. Gagnon, et al. (1992). “Occupation during life and memory performance in nondemented French elderly community residents.” Neurology 42(9): 1697-1701.

de Rijk, M. C., L. J. Launer, et al. (2000). “Prevalence of Parkinson’s disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group.” Neurology 54(11 Suppl 5): S21-23.

de Rijk, M. C., C. Tzourio, et al. (1997). “Prevalence of parkinsonism and Parkinson’s disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson’s disease.” J Neurol Neurosurg Psychiatry 62(1): 10-15.

Dealberto, M. J., M. Gagnon, et al. (1992). “[Influence of educational status on a screening test for dementia, the Mini-Mental State Examination].” Rev Epidemiol Sante Publique 40(2): 93-101.

3c. Information (i.e. research findings) expected to be gained from the population cohort
4a. Study criteria: age range of participants at recruitment
Age in years from: 65
To (‘until death’ if applicable): until death
4b. Study criteria: inclusion criteria

Persons aged 65 and over living at home and enrolled as voters in the Dordogne or Gironde

4c. Study criteria: exclusion criteria

People not living at home

5. Size of the cohort (i.e. number of participants enrolled)
  • 1,000 – 5,000 participants
6a. Measures used to characterise participants

age, sex, level of education, city of residence

6b. Additional measures for participants with a clinical disorder
6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)

Dementia and dependency, mortality

7. Study design
  • Prospective cohort
8. Cases matched by
  • Age
  • Sex
  • Co-morbidities
  • Cognitive function
  • Physical ability
9a. Does the study include a specialised subset of control participants
  • No
9b. If yes, description of specialised subset of control participants
10a. i) Data collection start date

01-01-1988

10a. ii) Data collection end date

01-01-2018

10a iii) Data collection for this study is
  • Data collection ongoing
  • Data analysis ongoing
  • Closed to new patients
10b. Plans to continue the cohort study beyond the current projected end date
  • No
11. Data collected
  • Only through the study
12. System in place to enable re-contact with patients for future studies
  • No
13a. Format and availability of data stored in a database
Yes/No % available
Data summarised in database  no
Database is web-based no
Database on spreadsheet no
Database is on paper no
Other (specify)  no

 

Language used:
13b. Format and availability of data held as individual records
Language used:
14a. Are data available to other groups

No

14b. Access policy/mechanisms for access if data are available to other groups
15. Data sharing policy specified as a condition of use
  • No policy exists
16a. Are tissues/samples/DNA available to other groups

No

16b. i) Description of available tissues/samples/DNA
16b. ii) Form available tissues/samples/DNA are supplied in
16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data
17. Is information on biological characteristics available to other groups
  • No

Types: Population Cohorts
Member States: France
Diseases: Alzheimer's disease & other dementias, Parkinson's disease & PD-related disorders
Years: 2011
Database Categories: N/A
Database Tags: N/A

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