Dr. Y.D. Reijmer
ConnectAD: connecting brain injury to cognitive outcome in Alzheimer's disease
Alzheimer's disease & other dementias
Alzheimers disease | amyloid | small vessel disease | cognition | white matter | brain connectivity | network | DTI
The mechanisms by which Alzheimers disease (AD) related processes cause cognitive impairment are incompletely understood. Elucidating these mechanisms is critical to identify effective treatment strategies to prevent AD-related cognitive decline. The overall aim of the proposed work is to elucidate a potential mechanism of AD-related cognitive decline: loss of white matter connectivity. Although AD is typically characterized as a gray matter disease, the white matter is also affected, even in pre-dementia stages. Healthy white matter is crucial for efficient neuronal signaling and information flow between brain regions.