Title of cohort

    Cooperative Health Research in the Augsburg Region

    Acronym for cohort

    KORA

    Name of Principal Investigator - Title

    Prof

    Name of Principal Investigator - First name

    Erich

    Name of Principal Investigator - Last name

    Wichmann

    Address of institution -Institution

    Helmholtz Zentrum München, German Research Center for Environmental Health

    Address of institution - Street address

    Ingolstädter Landstr. 1

    Address of institution - City

    Neuherberg

    Address of institution - Postcode

    85764

    Country

    Germany

    Funding source

    Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions?

    Neurodegenerative disease in general| Alzheimer's disease and other dementias| Parkinson's disease

    Q1b. When are studies on the above condition(s) expected to become possible?

    Already possible

    Q2a. In a single sentence what is the stated aim of the cohort?

    The aim of the cohort is to study behavioural, environmental and genetic risk factors for chronic diseases in the aging population and to study the role of subclinical intermediate phenotypes for disease development.

    Q2b. What distinguishes this cohort from other population cohorts?

    This is a population-based cohort and therefore will contain some persons with these disease. However, these patients are not identified by a clinical diagnosis but at best by a screening test

    Q3a. i) Number of publications that involve use of your cohort to date

    0

    Q3a.ii) Please give up to three examples of studies to date (Principal Investigator, Institution, Title of Study)

    Q3b. If data on research outputs are already available please paste the publication list/other data or provide a link to where these data are publicly available

    Q3c. If no research has been done as yet, please explain in a few sentences what information (i.e. research findings) you expect will be gained from the population

    Q4a. Study criteria: what is the age range of participants at recruitment? Age in years From:

    25

    Q4a. Study criteria: what is the age range of participants at recruitment? To:

    until death

    Q4b. Study criteria: what are the inclusion criteria?

    only residents of the Augsburg region (> 600,000 inhabitants), German nationality

    Q4c. Study criteria: what are the exclusion criteria?

    unable to communicate in German, too ill to participate in study examination

    Q5. What is the size of the cohort (i.e. how many participants have enrolled)?

    More than 15,000 participants

    Q6a. Please describe what measures are used to characterise participants

    please check the KORA website. We have an extensive phenotypic characterization (examinations, interview, questionnaires) including hundreds of variables. In addition, we have blood samples and other biomaterials from which genetic and metabolomic markers have been measured.

    Q6b. Are there additional measures for participants with a clinical disorder?

    Q6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)?

    If yes please specify

    Q7. What is the study design (select all that apply)?

    Prospective cohort

    Q8. Are your cases matched by

    Q9a. Does your study include a specialised subset of control participants?

    No

    Q9b. If your study includes a specialised subset of control participants please describe

    see Q8. Since all participants are selected from the population, they have several times been used as population controls.

    Q10a. i) Please enter the data collection start date

    01/01/1984

    Q10a. ii) Please enter the data collection end date

    Q10a. iii) Is data collection for this study

    Data collection ongoing

    Q10b. If data collection is ongoing, are there plans to continue the cohort study beyond the current projected end date?

    Yes - intend to apply for funding

    Q11. Is data collected

    Other please specify here

    Q12. Is there a system in place to enable re-contact with patients to ask about participation in future studies?

    Q13a. Please give information on the format and availability of data stored in a database (1)

    % available

    Q13a. Please give information on the format and availability of data stored in a database (2)

    % available

    Q13a. Please give information on the format and availability of data stored in a database (3)

    % available

    Q13a. Please give information on the format and availability of data stored in a database (4)

    % available

    Other (please specify)

    % available

    Q13b. Please give information on the format and availability of data held as individual records (1)

    % available

    Q13b. Please give information on the format and availability of data held as individual records (2)

    % available

    Q13b. Please give information on the format and availability of data held as individual records (3)

    % available

    Q13b. Please give information on the format and availability of data held as individual records (4)

    % available

    Please specify language used

    Q14a. Is data available to other groups?

    Yes

    Q14b. If data is available to other groups what is the access policy/mechanisms for access?

    Q15. What data sharing policy is specified as a condition of use?

    Data made publicly available after a specified time point

    Q16a. Are tissues/samples/DNA available to other groups?

    Yes

    Q16b i) If yes, please describe below:

    Q16b. ii) In what form are tissues/samples/DNA supplied?

    Q16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data (Q14 above)?

    Q17. Is information on biological characteristics available to other groups?

    Number of Patients

    % of total cohort

Types: Population Cohorts
Member States: Germany
Diseases: Alzheimer's disease & other dementias, Neurodegenerative disease in general, Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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