Name of Fellow


Prof Brett Garner

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment.

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 467,397

Start date of award


01/01/16

Total duration of award in years


5.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


alzheimer disease | apolipoprotein e | amyloid beta-protein | neurodegeneration | transgenic mouse

Research Abstract


Alzheimer’s disease (AD) is the major cause of dementia and is currently without a curative treatment. An understanding of the pathways that lead to AD is urgently required to develop approaches for treatments. We have discovered new pathways by which proteins called ApoE and ABCA7 control AD. We now aim to define precisely how these proteins work in the brain and use this information to develop therapeutic approaches to treat AD in humans.

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