Name of Fellow

    Prof Peter Cullen



    Wellcome Trust

    Contact information of fellow


    United Kingdom

    Title of project/programme

    Defining the role of retromer in endosomal sorting in health and disease.

    Source of funding information

    Wellcome Trust

    Total sum awarded (Euro)

    € 2,165,028

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Neurodegenerative disease in general


    Cognitive impairment | Dementia | Neurodegen | Parkinson

    Research Abstract

    Cells are composed of an outer boundary that is defined by a complex mixture of protein and lipids called the plasma membrane. This encircles a fluid filled 3-dimensional space, termed the cytosol, which contains additional membrane-encircled compartments each composed of a unique combination of proteins and lipids. For cells to function normally, proteins and lipids must be efficiently transported to the correct membrane-enriched compartment within this maze of membranes. Not surprisingly, if s uch transport is perturbed, so that the wrong proteins and lipids are delivered to the incorrect membrane-enriched compartment, cell function can be adversely affected which in turn leads to the development of various human diseases. Establishing the mechanisms through which cells achieve regulated protein and lipid transport is therefore a major challenge in cell biology with direct implication for our understanding of human disease. In the present proposal, we will explore the role of a pro tein complex called retromer in the control of protein transport within a specific aspect of the cells membraneous maze termed the endocytic network. In particular, we will define the emerging role of retromer in neuroprotection and how deregulation of this complex leads to neurodegenerative disease including Parkinson’s disease.

Types: Fellowships
Member States: United Kingdom
Diseases: Neurodegenerative disease in general
Years: 2016
Database Categories: N/A
Database Tags: N/A

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