University of Bristol
Evaluating the relationship between ischaemia and neurodegeneration in post-mortem brain tissue
Alzheimer's Research UK
Dementia is probably the largest healthcare challenge faced by society. Disorders such as high blood pressure and strokes that reduce blood flow to the brain substantially increase the risk of dementia, partly because they cause direct brain damage but also due to exacerbation of the abnormal changes in the brain that cause Alzheimer’s disease and possibly other dementias as well. In addition, Alzheimers itself causes stroke-like brain damage. Little is known about the ways in which reduced blood flow to the brain contributes to Alzheimer’s, or Alzheimer’s contributes to stroke-like brain damage. A major obstacle to elucidating these relationships has been the post-mortem detection of evidence of reduced blood flow in human brain tissue. We propose to conduct studies to establish reliable ways to measure the effects of reduced blood flow and to establish the extent and mechanisms of contribution of reduced blood flow to Alzheimer’s and other diseases that cause dementia.