University of Eastern Finland
Fingerprinting the risk of dementia and likelihood of intervention response to facilitate prevention-related decision-making
Academy of Finland
Dementia and Alzheimer disease prevention is a major public health priority. This project focuses on formulating tools for identifying high-risk individuals who may benefit from preventive interventions. Novel computer-based methods (Disease State Index, Disease State Fingerprint) will be used for analysis and visualization of a broad range of dementia-related factors and biomarkers. Specific aims include: 1) Risk index estimating an individuals risk of cognitive impairment/dementia; 2) Intervention response index estimating an individuals likelihood to respond to preventive interventions; 3) Planning a protocol for prevention-related decision-making. The project combines several large observational population-based studies (FINRISK, CAIDE, Vantaa 85+) and prevention trials (FINGER, MAPT, LipiDiDiet). It can produce comprehensive profiling tools that can facilitate personalization of preventive strategies in order to make them more effective.