Dr. M.W. Vernooij
Functional brain connectivity: a new imaging marker for preclinical dementia?
To fully assess the potential of assessment of resting-state network activity as a very early, preclinical marker of Alzheimers disease or other dementing disorders, a large-scale prospective population study is required in which participants undergo detailed examinations at baseline, including rs-fMRI, and are subsequently followed for the occurrence of dementia. The present project will perform rs-fMRI in 2,000 middle aged and elderly participants from the longitudinal population-based Rotterdam Study. Measures of functional brain connectitivity will be related to structural brain imaging markers and to known genetic and non-genetic risk factors for dementia. Furthermore, the association between functional connectivity and cognitive function and the risk of developing dementia will be assessed. The ultimate aim of this project is to evaluate the value of functional brain connectivity as a new imaging marker of preclinical dementia