Dr Sarah Rea
How do mutations in autophagy receptors cause FTD and ALS?
Alzheimer's disease & other dementias
proteomics | autophagy | cell signalling | protein interactions | dementia
As cells age the “garbage disposal” process within cells slows down, becoming less functional. In inherited forms of dementia the genes involved often code for damaged proteins that “clog up” the disposal system or directly affect the garbage men. These defective garbage men genes include SQSTM1/p62, OPTN, VCP and UBQLN2. We will determine how these defective genes lead to build up of garbage in neuronal cells and how leads to disease.