Name of Fellow

    Dr Frederick Livesey



    Wellcome Trust

    Contact information of fellow


    United Kingdom

    Title of project/programme

    Human stem cell models of Alzheimer's disease.

    Source of funding information

    Wellcome Trust

    Total sum awarded (Euro)

    € 2,797,489

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    alzheimer | Cognitive impairment | Dementia | Neurodegen

    Research Abstract

    We propose to use stem cell models of Alzheimer’s disease to ask and answer biological questions about the disease that have not been previously approachable: the study of AD initiation and pathogenesis in human forebrain neuronal networks, in real time. This programme depends on our fundamental research in developmental and stem cell biology and neuroscience, and associated technologies, such as genome engineering and imaging. That research underpins our ability to generate in vitro, glutamater gic cortical neural networks, which are the basis for functional studies of AD biology. We have used that system to study the development of Alzheimer’s disease pathologies in Down syndrome, including greatly increased Abeta peptide production, the formation of extracellular Abeta aggregates, changes in Tau phosphorylation and cellular localisation, release of extracellular Tau and cell death. Based on that work, we now propose to generate models of familial and sporadic Alzheimer’s disease, and use these models for functional experiments that address specific questions in AD: – How does AD progress and spread through the human nervous system? – How does AD affect neuronal function at the synapse and network level? – Can those changes be reversed? – How do AD-associated genetic variants contribute to disease initiation and progression in sporadic, late onset AD?

Types: Fellowships
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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