Dr. Nienke Timmer
Radboud university medical center, dept. anatomy, Nijmegen
Identification of novel a?-associated proteins
alzheimer nederland (ISAO)
The amyloid β (Aβ) protein is crucial in the pathogenesis of Alzheimer’s disease (AD), but its fate is affected by interaction with A?-associated proteins such as ApoE and heparan sulphate proteoglycans. Usually, end-stage AD brain tissue is used to identify Aβ-associated proteins. We postulate that hitherto unknown Aβ-binding proteins, that play a role in the earliest stages of plaque development, may shed new light on the way Aβ is deposited. With a recently established method using soluble Aβ as bait, we aim to identify these novel early Aβ-binding proteins.