University of Edinburgh
Imaging cerebral vascular alterations and their modulation in experimental models: a translational approach
Alzheimer's Research UK
Alterations in the vascular system, supplying blood to the brain, may be the primary trigger in the development of sporadic Alzheimers disease (AD) and cause memory loss. The ability to detect and improve vascular alterations could be critical to improve the prognosis of the disease. A brain imaging technique known as magnetic resonance angiography (MRA) is commonly used to visualise human brain vasculature. This approach has been modified for imaging rodent vasculature, known as contrast enhanced MRA, (CE-MRA) where it may have utility to study vascular changes in mouse models relevant to AD. This studentship will employ well-characterised models relevant to AD which we have evidence cause vascular alterations and now wish to determine whether we can visualise these changes in the brain using in vivo imaging. The effect of drugs that act on the vasculature will also be studied. As part of the project it will be determined whether in vivo imaging approaches are sufficiently sensitive to detect alterations in the brain vasculature in these models. The overarching aim of the proposal is to develop CE-MRA as a non-invasive tool to visualise vascular alterations and to test the effectiveness of putative disease modifying interventions in models of disease.