Title of project or programme

Improving mental health of older people through multidisciplinary efforts

Principal Investigators of project/programme grant
Title Forname Surname Institution Country
Professor Knut Engedal University of Oslo Norway
Address of institution of lead PI
Institution University of Oslo
Street Address PO Box 1072 Blindern
City Oslo
Postcode NO-0316


Source of funding information

The Research Council of Norway

Total sum awarded (Euro)


Start date of award


Total duration of award in months


The project/programme is most relevant to
  • Neurodegenerative disease in general

RCT, mental health, multidiciplinary

Research abstract in English

We have built a multidisciplinary consortium of eight research groups in order to provide new knowledge on mental health in older people and to improve services for this group of patients. In addition, national and international partners will be involved. The study will start in 2009 and have last for four years.Three patient cohorts, known to have a high prevalence of depression, dementia and delirium, will be studied; 800 with hip fracture, 1000 attending a memory clinic, and 1000 receiving in home nu rsing care. Cross-sectional and longitudinal designs will be used to describe the cohorts, and randomised controlled trials will be carried out to study the effect of pharmacological and nonpharmacological interventions within them. A common set of core v ariables will be utilised for all patients, describing symptoms of depression, dementia, delirium, frailty and disabilities. For a subpopulation, physical activity and the influence of physical activity on mental health will be studied. For another subpopulation, serum and whole blood will be collected for analysis of proinflammatory cytokins, cytochrom P450 genotype, drug concentrations, and other biological markers. During the follow-up of all patients of at least three years, the transition to nursing home placement and in-home nursing care will be studied. The project has two phases. The first is the observational phase, where the three patient populations will be examined and followed up. The second consists of three interventional trials: a) a RCT to study the effect of physical exercise on depressive symptoms in patients with mild cognitive impairment or mild dementia combined with depression, b) a RCT that will study the effect of a comprehensive orthogeriatric unit for hip fracture patients, an d c) a double blind RCT to study the effect of haloperidol in the prevention and treatment of deliriu.

Lay summary

Types: Investments > €500k
Member States: Norway
Diseases: Neurodegenerative disease in general
Years: 2011
Database Categories: N/A
Database Tags: N/A

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