Prof. dr. Johannes de Boer
VU University of Amsterdam, Dept. of Physics and Astronomy
In vivo optische detectie van Amyloid Beta plaques in de menselijke retina. In vivo optical detection of Amyloid Beta plaques in the human retina
alzheimer nederland (ISAO)
At present A? plaque burden is the most important pathological parameter in Alzheimers disease (AD) for diagnosis and monitoring of disease progression. We propose to use a novel retinal amyloid imaging technique in order to develop a biomarker for AD that can be easily obtained with minimal patient discomfort. This will enable early diagnosis. In addition, visualization of A? plaques in the retina will be an ideal patient friendly procedure for evaluation of the effects of new therapeutic agents. A new method with minimal cost and patient discomfort will have a huge impact on dementia care, health care costs and quality of life.