Dr Vanessa Morris
Investigating the toxic particles formed by the Alzheimer's disease protein amyloid-beta
Alzheimer's disease & other dementias
structural biology | biophysics | protein aggregation | amyloid | nuclear magnetic resonance (nmr) spectroscopy
Alzheimers disease is a devastating neurodegenerative disease that currently affects 240 000 Australians. The protein called amyloid-ß is found in deposits in the brains of Alzheimers patients. The toxic form of this protein is thought to be small aggregated particles called oligomers. This work aims to investigate the structure of these particles, the reason why they are toxic, as well as their interaction with the neuroprotective compound EGCG, which is found in green tea.