Prof Brett Garner
University of Wollongong
Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimers disease risk.
National Health and Medical Research Council
We recently discovered that a protein called apoE is cleaved in the brain to generate a small fragment that may have neuroprotective properties. We also discovered that human induced pluripotent stem cell (iPSC)-derived neurons produce apoE fragments identical to those in the brain. We will now characterise iPSC apoE and assess its neuroprotective properties. This will resolve the basis for the association of apoE with AD risk and potentially provide a new target for AD treatment.