Principal Investigators


Prof Brett Garner

Institution


University of Wollongong

Contact information of lead PI


Country


Australia

Title of project or programme


Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer’s disease risk.

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 286,639

Start date of award


01/01/2015

Total duration of award in years


3

Keywords


Research Abstract


We recently discovered that a protein called apoE is cleaved in the brain to generate a small fragment that may have neuroprotective properties. We also discovered that human induced pluripotent stem cell (iPSC)-derived neurons produce apoE fragments identical to those in the brain. We will now characterise iPSC apoE and assess its neuroprotective properties. This will resolve the basis for the association of apoE with AD risk and potentially provide a new target for AD treatment.

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