Dr Gabriela Bodea
L1 retrotransposition: the missing link between genetics and environmental factors in Parkinson's disease ?
Alzheimer's disease & other dementias
dementia | dopamine | epigenetics | parkinson disease | molecular basis of disease
The study proposed here focuses on understanding the role of specific mobile DNA sequences in the interaction between environmental and genetic risk factors causing Parkinsons disease (PD) leading to dementia. The project proposes identification of mobile DNA induced mutations in post-mortem human PD patient brain samples. The significance and mechanisms of mobile DNA induced mutations will be then tested in a PD mouse model.