Principal Investigators


Dr. A.W. Lemstra

Institution


VU medisch centrum

Contact information of lead PI


Country


Netherlands

Title of project or programme


Longitudinal DLB Cohort

Source of funding information


Alzheimer Nederland

Total sum awarded (Euro)


€ 155,000

Start date of award


01/09/2015

Total duration of award in years


4

Keywords


Research Abstract


Dementia with Lewy Bodies (DLB) is a devastating neurodegenerative disease that. It is the most common form of dementia next to Alzheimer’s disease (around 30.000-50.000 patients in the Netherlands). The overall aim of this project is to investigate the clinical relevance of AD-pathology in early stages of DLB and to understand the biological factors that contribute to this effect, in order to improve care and offer personalized treatment strategies for DLB-patients. AD-pathology is detected by CSF-biomarkers.
The following objectives are specified:
1) To compare cross-sectional data in DLB-AD+ and DLB-AD- clinical symptoms, neuropsychological profile, MRI-characteristics (atrophy, vascular lesions) and EEG
2) To compare disease progression and survival (nursing home admission and death) in DLB-AD+ and DLB-AD- patients. Longitudinal clinical data, neuropsychological data as well as biomarkers will be analysed
3) To compare genetic profiles of DLB-AD+ and DLB-AD- by analysis of NeuroX analyses of DNA of DLB-patients
4) To compare levels of CSF amyloid-beta species (Abeta38/40/42) in DLB-AD+, DLB-AD and AD
5) To compare histopathological features in a subset of autopsy-proven DLB-patients

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