A/Pr Brett Collins
University of Queensland
Membrane trafficking in Alzheimer's disease
National Health and Medical Research Council
Alzheimers disease is a progressive neurological disorder and is the most common cause of dementia. No effective treatments are currently available. The toxic amyloid peptide is central to disease pathology and is derived from breakdown of the Alzheimers amyloid precursor protein (APP). In this project we will examine the interactions between APP and the molecular machinery that controls its location in the cell and subsequent degradation.